Schlafen, GTPase-like domain

Definition

This domain is found in groups II and III of Schlafen (SLFN) proteins, which follows the AlbA_2 domain ([interpro:IPR007421]). In group II, this is the C-terminal domain, while in group III members it localises in the central region, followed by a C-terminal helicase domain ([interpro:IPR018647]). This domain has been described as a GTPase-like domain and it contains the SLFN-specific SWADL motif [[cite:PMID:34707099], [cite:PMID:34272366], [cite:PMID:23570387], [cite:PMID:31026779], [cite:PMID:34571887]]. SLFN proteins are involved in the control of cell proliferation, induction of immune responses, and the regulation of viral replication. Mouse and human members are regulated by interferons PMID:23570387. In SLFN12, this is the C-terminal domain which contains crucial residues for interaction with PDE3A PMID:34707099. By analogy with dynamin and MxB, this domain in SLFN12 may contribute to chromatin and actin cytoskeleton interactions, involved in cell differentiation PMID:31026779. SLFN proteins share common domains and a high degree of homology, however, they have specific and sometimes, opposing effects in some cancer types PMID:34571887.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• SLFN11
• SLFN12
• SLFN12L
• SLFN13
• SLFN14
• SLFN5