Schlafen family
IPR029684
Definition
The Schlafen (SLFN) family includes several mouse and human member genes that have been implicated in important functions, such as the control of cell proliferation, induction of immune responses, and the regulation of viral replication [[cite:PMID:23570387], [cite:PMID:34707099], [cite:PMID:34272366], [cite:PMID:28460425]]. Mouse and human SLFN proteins are regulated by interferons (IFNs) PMID:23570387. All SLFNs contain an unique Slfn box. SLFN family is comprised of 3 groups, based on the size of the encoded proteins [[cite:PMID:23570387], [cite:PMID:28460425], [cite:PMID:15351786], [cite:PMID:18355440]]: Group1: Slfn1, Slfn2, and Slfn Like 1. Group2: Slfn3, Slfn4 and Slfn12. Group3: Slfn5, Slfn8-11, Slfn13 and Slfn14. Comparing to group1 proteins, group2 and 3 proteins contain an extra SWADL domain C terminus to the AAA domain. Group3 proteins also possess a large extension C terminus to their SWADL domain. This C-terminal extension is homologous to the superfamily I of DNA/RNA helicases PMID:18355440. It has been proposed that the divergent AAA ATPase domain may function as an RNA-binding domain PMID:34272366. This entry also includes orthopoxvirus sequences. Analyses indicate that a member of the Schlafen family was horizontally transferred from murine rodents to orthopoxviruses, where it is hypothesised to play a role in allowing the virus to survive host immune defense mechanisms PMID:19619625.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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