Seroatlas · Human Serome Atlas

TSPAN15

Tetraspanin-15

Also known as: NET-7, TM4SF15, TSN15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95858
Gene: TSPAN15
Ensembl: ENSG00000099282
Chromosome: 10
Canonical length: 294 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nuclear bodies,Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

294 residues, UniProt reviewed canonical sequence.

>O95858|TSPAN15
     1  MPRGDSEQVR YCARFSYLWL KFSLIIYSTV FWLIGALVLS VGIYAEVERQ KYKTLESAFL
    61  APAIILILLG VVMFMVSFIG VLASLRDNLY LLQAFMYILG ICLIMELIGG VVALTFRNQT
   121  IDFLNDNIRR GIENYYDDLD FKNIMDFVQK KFKCCGGEDY RDWSKNQYHD CSAPGPLACG
   181  VPYTCCIRNT TEVVNTMCGY KTIDKERFSV QDVIYVRGCT NAVIIWFMDN YTIMAGILLG
   241  ILLPQFLGVL LTLLYITRVE DIIMEHSVTD GLLGPGAKPS VEAAGTGCCL CYPN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPAN15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 98 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 98 nTPM
stomach: 71 nTPM
adipose tissue: 67 nTPM
colon: 60 nTPM
breast: 59 nTPM
urinary bladder: 45 nTPM

Single-cell type

urothelial cells: 230 nCPM
foveolar cells: 149 nCPM
alveolar cells type 1: 146 nCPM
oligodendrocytes: 135 nCPM
colonocytes: 127 nCPM
adipocytes: 123 nCPM

Immune cell

MAIT T-cell: 20 nTPM
myeloid DC: 3.3 nTPM
memory CD4 T-cell: 3.1 nTPM
memory CD8 T-cell: 2.8 nTPM
gdT-cell: 2.3 nTPM
T-reg: 1.1 nTPM

Brain region

white matter: 106 nTPM
medulla oblongata: 56 nTPM
basal ganglia: 55 nTPM
cerebellum: 51 nTPM
thalamus: 50 nTPM
midbrain: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.01
gnomAD missense Z: 0.88
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

enzyme binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSPAN15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPAN15 as an antibody target. Whether an autoantibody or antibody against TSPAN15 could matter depends on whether native TSPAN15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPAN15 is annotated at the cell surface, where native TSPAN15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TSPAN15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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