YIPF4
Protein YIPF4
Also known as: FinGER4, MGC11061, YIPF4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BSR8
- Gene
- YIPF4
- Ensembl
- ENSG00000119820
- Chromosome
- 2
- Canonical length
- 244 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Golgi apparatus,Vesicles,Plasma membrane
OverviewNCBI Gene
Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Located in Golgi apparatus; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
244 residues, UniProt reviewed canonical sequence.
>Q9BSR8|YIPF4
1 MQPPGPPPAY APTNGDFTFV SSADAEDLSG SIASPDVKLN LGGDFIKEST ATTFLRQRGY
61 GWLLEVEDDD PEDNKPLLEE LDIDLKDIYY KIRCVLMPMP SLGFNRQVVR DNPDFWGPLA
121 VVLFFSMISL YGQFRVVSWI ITIWIFGSLT IFLLARVLGG EVAYGQVLGV IGYSLLPLIV
181 IAPVLLVVGS FEVVSTLIKL FGVFWAAYSA ASLLVGEEFK TKKPLLIYPI FLLYIYFLSL
241 YTGVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against YIPF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 5
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 17 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 17 nTPM
- pancreas: 14 nTPM
- cerebral cortex: 12 nTPM
- retina: 12 nTPM
- thyroid gland: 9.4 nTPM
- liver: 8.6 nTPM
Single-cell type
- esophageal apical cells: 551 nCPM
- neutrophils: 336 nCPM
- breast lactating cells: 313 nCPM
- syncytiotrophoblasts: 295 nCPM
- early primary spermatocytes: 169 nCPM
- myonuclei: 138 nCPM
Immune cell
- basophil: 15 nTPM
- neutrophil: 15 nTPM
- NK-cell: 6.3 nTPM
- eosinophil: 5.7 nTPM
- classical monocyte: 5.3 nTPM
- plasmacytoid DC: 5.3 nTPM
Brain region
- white matter: 50 nTPM
- cerebral cortex: 40 nTPM
- pons: 40 nTPM
- hippocampal formation: 38 nTPM
- medulla oblongata: 34 nTPM
- amygdala: 33 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.77
- gnomAD pLI
- 0.06
- gnomAD missense Z
- 0.34
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of YIPF4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads YIPF4 as an antibody target. Whether an autoantibody or antibody against YIPF4 could matter depends on whether native YIPF4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
YIPF4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label YIPF4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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