Neutral amino acid SLC6 transporter

Definition

Solute carrier 6 (SLC6) transporters are part of the neurotransmitter:sodium symporters family. This entry represents a group of neutral amino acid SLC6 transporters that includes B0AT1 (SLC6A19), B0AT3 (SLC6A18), B0AT2 (SLC6A15), NTT4/XT1 (SLC6A17) and XTRP3/XT3 (SLC6A20) PMID:23506866. B0AT1 (SLC6A19) catalyzes the secondary active transport of neutral amino acids across the apical membrane in the small intestine and kidney, whereas B0AT3 (SLC6A18) is found only in the kidney PMID:23876153. Human B0AT3 is an inactive protein, which explains the absence of glycinuria in humans with homozygous nonsense mutations in B0AT3. Mouse B0AT3 requires collectrin both for trafficking of the transporter to the cell surface and for the catalytic activity PMID:26240152.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• SLC6A15
• SLC6A17
• SLC6A18
• SLC6A19
• SLC6A20