Seroatlas · Human Serome Atlas

SLC25A5

ADP/ATP translocase 2

Also known as: 2F1, ADT2_HUMAN, ANT2, T2, T3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P05141
Gene
SLC25A5
Ensembl
ENSG00000005022
Chromosome
X
Canonical length
298 aa
Protein class
FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>P05141|SLC25A5
     1  MTDAAVSFAK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQITADKQ YKGIIDCVVR
    61  IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDKRTQFW LYFAGNLASG
   121  GAAGATSLCF VYPLDFARTR LAADVGKAGA EREFRGLGDC LVKIYKSDGI KGLYQGFNVS
   181  VQGIIIYRAA YFGIYDTAKG MLPDPKNTHI VISWMIAQTV TAVAGLTSYP FDTVRRRMMM
   241  QSGRKGTDIM YTGTLDCWRK IARDEGGKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
696 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 696 nTPM
  • pancreas: 579 nTPM
  • small intestine: 530 nTPM
  • rectum: 472 nTPM
  • kidney: 459 nTPM
  • stomach: 452 nTPM

Single-cell type

  • parietal cells: 3,996 nCPM
  • enterocytes: 2,510 nCPM
  • syncytiotrophoblasts: 1,855 nCPM
  • esophageal basal cells: 1,848 nCPM
  • colonocytes: 1,652 nCPM
  • esophageal suprabasal cells: 1,471 nCPM

Immune cell

  • intermediate monocyte: 1,046 nTPM
  • total PBMC: 931 nTPM
  • myeloid DC: 873 nTPM
  • non-classical monocyte: 828 nTPM
  • classical monocyte: 604 nTPM
  • plasmacytoid DC: 477 nTPM

Brain region

  • hypothalamus: 149 nTPM
  • cerebellum: 149 nTPM
  • thalamus: 116 nTPM
  • pons: 116 nTPM
  • cerebral cortex: 113 nTPM
  • white matter: 107 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.93
gnomAD missense Z
2.65
DepMap mean gene effect
-0.41
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC25A5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A5 as an antibody target. Whether an autoantibody or antibody against SLC25A5 could matter depends on whether native SLC25A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC25A5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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