Seroatlas · Human Serome Atlas

ARHGAP11B

Inactive Rho GTPase-activating protein 11B

Also known as: B'-T, FAM7B1, RHGBB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3KRB8
Gene: ARHGAP11B
Ensembl: ENSG00000285077
Chromosome: 15
Canonical length: 267 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Involved in cerebral cortex development and negative regulation of mitochondrial membrane permeability. Acts upstream of with a positive effect on glutamine catabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

267 residues, UniProt reviewed canonical sequence.

>Q3KRB8|ARHGAP11B
     1  MWDQRLVKLA LLQHLRAFYG IKVKGVRGQC DRRRHETAAT EIGGKIFGVP FNALPHSAVP
    61  EYGHIPSFLV DACTSLEEHI HTEGLFRKSG SVIRLKALKN KVDHGEGCLS SAPPCDIAGL
   121  LKQFFRELPE PILPADLHEA LLKAQQLGTE EKNKAILLLS CLLADHTVHV LRYFFNFLRN
   181  VSLRSSENKM DSSNLAVIFA PNLLQTSEGH EKMSSNAEKK GVYQTLSWKR YQPCWVLMVS
   241  VLLHHWKALK KVNMKLLVNI REREDNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP11B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 4.7 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 4.7 nTPM
lymph node: 1.3 nTPM
thymus: 1.3 nTPM
appendix: 1.2 nTPM
esophagus: 0.9 nTPM
tonsil: 0.8 nTPM

Single-cell type

enteric transient amplifying cells: 3.6 nCPM
extravillous trophoblasts: 1.5 nCPM
foveolar cells: 1.1 nCPM
gastric chief cells: 1.1 nCPM
enteric stem cells: 1 nCPM
kupffer cells: 1 nCPM

Immune cell

basophil: 0.9 nTPM
naive B-cell: 0.5 nTPM
memory CD4 T-cell: 0.4 nTPM
plasmacytoid DC: 0.3 nTPM
memory B-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

choroid plexus: 1.6 nTPM
medulla oblongata: 1.3 nTPM
hypothalamus: 1.1 nTPM
midbrain: 1.1 nTPM
pons: 1.1 nTPM
spinal cord: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: -0.35

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGAP11B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP11B as an antibody target. Whether an autoantibody or antibody against ARHGAP11B could matter depends on whether native ARHGAP11B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP11B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGAP11B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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