Seroatlas · Human Serome Atlas

SIRT4

NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

Also known as: SIR2L4, SIR4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6E7
Gene
SIRT4
Ensembl
ENSG00000089163
Chromosome
12
Canonical length
314 aa
Protein class
Cancer-related genes, Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q9Y6E7|SIRT4
     1  MKMSFALTFR SAKGRWIANP SQPCSKASIG LFVPASPPLD PEKVKELQRF ITLSKRLLVM
    61  TGAGISTESG IPDYRSEKVG LYARTDRRPI QHGDFVRSAP IRQRYWARNF VGWPQFSSHQ
   121  PNPAHWALST WEKLGKLYWL VTQNVDALHT KAGSRRLTEL HGCMDRVLCL DCGEQTPRGV
   181  LQERFQVLNP TWSAEAHGLA PDGDVFLSEE QVRSFQVPTC VQCGGHLKPD VVFFGDTVNP
   241  DKVDFVHKRV KEADSLLVVG SSLQVYSGYR FILTAWEKKL PIAILNIGPT RSDDLACLKL
   301  NSRCGELLPL IDPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIRT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
9.1 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 9.1 nTPM
  • tongue: 6.7 nTPM
  • testis: 5.8 nTPM
  • cerebellum: 4.3 nTPM
  • heart muscle: 4.2 nTPM
  • liver: 3.7 nTPM

Single-cell type

  • late primary spermatocytes: 42 nCPM
  • early spermatids: 39 nCPM
  • myonuclei: 28 nCPM
  • rod photoreceptor cells: 17 nCPM
  • retinal ganglion cells: 16 nCPM
  • enterocytes: 12 nCPM

Immune cell

  • basophil: 6.8 nTPM
  • MAIT T-cell: 5.8 nTPM
  • naive CD4 T-cell: 4.4 nTPM
  • naive CD8 T-cell: 3.9 nTPM
  • gdT-cell: 3.8 nTPM
  • plasmacytoid DC: 3.8 nTPM

Brain region

  • cerebellum: 5.4 nTPM
  • cerebral cortex: 4.1 nTPM
  • choroid plexus: 4.1 nTPM
  • basal ganglia: 3.7 nTPM
  • white matter: 3.7 nTPM
  • pons: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.77
gnomAD pLI
0
gnomAD missense Z
1.01
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIRT4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIRT4 as an antibody target. Whether an autoantibody or antibody against SIRT4 could matter depends on whether native SIRT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIRT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SIRT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SIRT4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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