Seroatlas · Human Serome Atlas

EMB

Embigin

Also known as: EMB_HUMAN, MGC71745

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PCB8
Gene: EMB
Ensembl: ENSG00000170571
Chromosome: 5
Canonical length: 327 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a transmembrane glycoprotein that is a member of the immunoglobulin superfamily. The encoded protein may be involved in cell growth and development by mediating interactions between the cell and extracellular matrix. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q6PCB8|EMB
     1  MRALPGLLEA RARTPRLLLL QCLLAAARPS SADGSAPDSP FTSPPLREEI MANNFSLESH
    61  NISLTEHSSM PVEKNITLER PSNVNLTCQF TTSGDLNAVN VTWKKDGEQL ENNYLVSATG
   121  STLYTQYRFT IINSKQMGSY SCFFREEKEQ RGTFNFKVPE LHGKNKPLIS YVGDSTVLTC
   181  KCQNCFPLNW TWYSSNGSVK VPVGVQMNKY VINGTYANET KLKITQLLEE DGESYWCRAL
   241  FQLGESEEHI ELVVLSYLVP LKPFLVIVAE VILLVATILL CEKYTQKKKK HSDEGKEFEQ
   301  IEQLKSDDSN GIENNVPRHR KNESLGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EMB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 161 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 161 nTPM
duodenum: 70 nTPM
small intestine: 67 nTPM
lymph node: 57 nTPM
tonsil: 49 nTPM
skin: 32 nTPM

Single-cell type

neutrophil progenitors: 1,921 nCPM
neutrophils: 837 nCPM
monocyte progenitors: 393 nCPM
t-cells: 363 nCPM
nk-cells: 261 nCPM
cone photoreceptor cells: 261 nCPM

Immune cell

MAIT T-cell: 55 nTPM
T-reg: 55 nTPM
gdT-cell: 45 nTPM
total PBMC: 43 nTPM
memory CD8 T-cell: 42 nTPM
memory CD4 T-cell: 41 nTPM

Brain region

midbrain: 23 nTPM
medulla oblongata: 20 nTPM
pons: 18 nTPM
hypothalamus: 17 nTPM
cerebellum: 14 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: -0.56
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cell-cell adhesion mediator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EMB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EMB as an antibody target. Whether an autoantibody or antibody against EMB could matter depends on whether native EMB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EMB is annotated at the cell surface, where native EMB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EMB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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