GRID2IP

Protein identityUniProt · HPA

UniProt accession

A4D2P6

Gene

GRID2IP

Ensembl

ENSG00000215045

Chromosome

7

Canonical length

1211 aa

Protein class

Predicted intracellular proteins

Subcellular location

Plasma membrane

OverviewNCBI Gene

Glutamate receptor delta-2 (GRID2; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purkinje cells (Matsuda et al., 2006 [PubMed 16835239]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

1211 residues, UniProt reviewed canonical sequence.

>A4D2P6|GRID2IP
     1  MATTATPATN QGWPEDFGFR LGGSGPCFVL EVAKGSSAHA GGLRPGDQIL EVEGLAVGGL
    61  SRERLVRLAR RCPRVPPSLG VLPAPDGGPG PGSGPAAPTT VLRAPRCGRG LALGRELLRL
   121  AGRKRPDAVH RERRRKAQEF SRKVDEILGD QPTAKEQVFA ALKQFAAEQR VDDLVWTLTL
   181  ALPREACGPL LDNLRIFIPK KHRARFDEVV SQGLLGKLCR ARRAQGAQRL RRSRSEERPE
   241  RLLVSTRASA PPRRPDEPPP RRASLLVGGL AGPGGARRTV RVYKGNKSFG FTLRGHGPVW
   301  IESVLPGSPA DNAALKSGDR ILFLNGLDMR NCSHDKVVSM LQGSGAMPTL VVEEGLVPFA
   361  SDSDSLDSPN PSSALTSLQW VAEILPSSIR VQGRTFSQQL EHLLTPPERY GVCRALESFF
   421  QHRNIDTLIV DVYPVLDTPA KQVLWQFIYQ LLTYEEQELC QEKIACFLGY TAMTAEPEPE
   481  LDLESEPTPE PQPRSSLRAS SMCRRSLRSQ GLEAGLSCGP SECPEMPLPL IPGERQAGDG
   541  TSLPETPNPK MMSAVYAELE SRLNSSFKGK MGTVSKSRAS PPGPSPAVTT GPRTLSGVSW
   601  PSERLLPSPC YHPLCSGGLA SPSSSESHPY ASLDSSRAPS PQPGPGPICP DSPPSPDPTR
   661  PPSRRKLFTF SHPVRSRDTD RFLDVLSEQL GPRVTIVDDF LTPENDYEEM SFHDDQGSFV
   721  TNERSSASDC ISSSEEGSSL TYSSISDHIP PPPLSPPPPP PLPFHDAKPS SRSSDGSRGP
   781  AQALAKPLTQ LSHPVPPPPP PPLPPPVPCA PPMLSRGLGH RRSETSHMSV KRLRWEQVEN
   841  SEGTIWGQLG EDSDYDKLSD MVKYLDLELH FGTQKPAKPV PGPEPFRKKE VVEILSHKKA
   901  YNTSILLAHL KLSPAELRQV LMSMEPRRLE PAHLAQLLLF APDADEEQRY QAFREAPGRL
   961  SEPDQFVLQM LSVPEYKTRL RSLHFQATLQ EKTEEIRGSL ECLRQASLEL KNSRKLAKIL
  1021  EFVLAMGNYL NDGQPKTNKT TGFKINFLTE LNSTKTVDGK STFLHILAKS LSQHFPELLG
  1081  FAQDLPTVPL AAKVNQRALT SDLADLHGTI SEIQDACQSI SPSSEDKFAM VMSSFLETAQ
  1141  PALRALDGLQ REAMEELGKA LAFFGEDSKA TTSEAFFGIF AEFMSKFERA LSDLQAGEGL
  1201  RSSGMVSPLA W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRID2IP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

2.4 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.42

gnomAD pLI

0.12

gnomAD missense Z

1.07

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• long-term synaptic depression
• regulation of postsynaptic cytosolic calcium ion concentration
• regulation of postsynaptic membrane neurotransmitter receptor levels

Cellular components

• cerebellar granule cell to Purkinje cell synapse
• parallel fiber to Purkinje cell synapse
• postsynaptic density, intracellular component
• postsynaptic membrane

Protein domainsUniProt · Pfam · InterPro

• PDZ domain
• Formin, FH2 domain
• PDZ superfamily
• Formin, FH2 domain superfamily
• Formin Homology
• PDZ domain
• Formin Homology 2 Domain

KeywordsUniProt

• Cell membrane
• Membrane
• Phosphoprotein
• Postsynaptic cell membrane
• Repeat
• Synapse

InteractionsUniProt · HPA

Protein binding partners of GRID2IP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GRID2
• SLC16A7