Monocarboxylate transporter
IPR004743
Definition
Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [[cite:PMID:9425115], [cite:PMID:22131303]]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7. Four mammalian isoforms, MCTs 1-4, have been identified, each with distinct substrate and inhibitor affinities PMID:22131303. MCT1-4 have been linked to cancer maintenance and aggressiveness PMID:22407107.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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