Seroatlas · Human Serome Atlas

GFPT2

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

Also known as: GFAT2, GFPT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94808
Gene: GFPT2
Ensembl: ENSG00000131459
Chromosome: 5
Canonical length: 682 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Involved in UDP-N-acetylglucosamine biosynthetic process and fructose 6-phosphate metabolic process. Predicted to be located in cytosol. Implicated in type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

682 residues, UniProt reviewed canonical sequence.

>O94808|GFPT2
     1  MCGIFAYMNY RVPRTRKEIF ETLIKGLQRL EYRGYDSAGV AIDGNNHEVK ERHIQLVKKR
    61  GKVKALDEEL YKQDSMDLKV EFETHFGIAH TRWATHGVPS AVNSHPQRSD KGNEFVVIHN
   121  GIITNYKDLR KFLESKGYEF ESETDTETIA KLIKYVFDNR ETEDITFSTL VERVIQQLEG
   181  AFALVFKSVH YPGEAVATRR GSPLLIGVRS KYKLSTEQIP ILYRTCTLEN VKNICKTRMK
   241  RLDSSACLHA VGDKAVEFFF ASDASAIIEH TNRVIFLEDD DIAAVADGKL SIHRVKRSAS
   301  DDPSRAIQTL QMELQQIMKG NFSAFMQKEI FEQPESVFNT MRGRVNFETN TVLLGGLKDH
   361  LKEIRRCRRL IVIGCGTSYH AAVATRQVLE ELTELPVMVE LASDFLDRNT PVFRDDVCFF
   421  ISQSGETADT LLALRYCKDR GALTVGVTNT VGSSISRETD CGVHINAGPE IGVASTKAYT
   481  SQFISLVMFG LMMSEDRISL QNRRQEIIRG LRSLPELIKE VLSLEEKIHD LALELYTQRS
   541  LLVMGRGYNY ATCLEGALKI KEITYMHSEG ILAGELKHGP LALIDKQMPV IMVIMKDPCF
   601  AKCQNALQQV TARQGRPIIL CSKDDTESSK FAYKTIELPH TVDCLQGILS VIPLQLLSFH
   661  LAVLRGYDVD FPRNLAKSVT VE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GFPT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 108 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 108 nTPM
urinary bladder: 36 nTPM
ovary: 32 nTPM
fallopian tube: 30 nTPM
heart muscle: 28 nTPM
lung: 25 nTPM

Single-cell type

epicardial cells: 914 nCPM
mesothelial cells: 422 nCPM
fibroblasts: 281 nCPM
decidual stromal cells: 208 nCPM
fibro-adipogenic progenitors: 194 nCPM
endometrial stromal cells: 138 nCPM

Immune cell

MAIT T-cell: 3.5 nTPM
memory CD8 T-cell: 1.2 nTPM
gdT-cell: 0.7 nTPM
naive CD8 T-cell: 0.5 nTPM
memory CD4 T-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM

Brain region

medulla oblongata: 48 nTPM
white matter: 31 nTPM
cerebellum: 30 nTPM
pons: 28 nTPM
cerebral cortex: 25 nTPM
hypothalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 1.55
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GFPT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SIRT6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GFPT2 as an antibody target. Whether an autoantibody or antibody against GFPT2 could matter depends on whether native GFPT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GFPT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GFPT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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