Seroatlas · Human Serome Atlas

NCAPD2

Condensin complex subunit 1

Also known as: CAP-D2, CNAP1, CND1_HUMAN, hCAP-D2, KIAA0159

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15021
Gene: NCAPD2
Ensembl: ENSG00000010292
Chromosome: 12
Canonical length: 1401 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Centriolar satellite,Cytosol

OverviewNCBI Gene

Enables histone binding activity. Involved in mitotic chromosome condensation and positive regulation of chromosome condensation. Located in several cellular components, including condensed chromosome; microtubule organizing center; and nuclear lumen. Part of condensin complex. Implicated in primary autosomal recessive microcephaly 21. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1401 residues, UniProt reviewed canonical sequence.

>Q15021|NCAPD2
     1  MAPQMYEFHL PLSPEELLKS GGVNQYVVQE VLSIKHLPPQ LRAFQAAFRA QGPLAMLQHF
    61  DTIYSILHHF RSIDPGLKED TLQFLIKVVS RHSQELPAIL DDTTLSGSDR NAHLNALKMN
   121  CYALIRLLES FETMASQTNL VDLDLGGKGK KARTKAAHGF DWEEERQPIL QLLTQLLQLD
   181  IRHLWNHSII EEEFVSLVTG CCYRLLENPT INHQKNRPTR EAITHLLGVA LTRYNHMLSA
   241  TVKIIQMLQH FEHLAPVLVA AVSLWATDYG MKSIVGEIVR EIGQKCPQEL SRDPSGTKGF
   301  AAFLTELAER VPAILMSSMC ILLDHLDGEN YMMRNAVLAA MAEMVLQVLS GDQLEAAARD
   361  TRDQFLDTLQ AHGHDVNSFV RSRVLQLFTR IVQQKALPLT RFQAVVALAV GRLADKSVLV
   421  CKNAIQLLAS FLANNPFSCK LSDADLAGPL QKETQKLQEM RAQRRTAAAS AVLDPEEEWE
   481  AMLPELKSTL QQLLQLPQGE EEIPEQIANT ETTEDVKGRI YQLLAKASYK KAIILTREAT
   541  GHFQESEPFS HIDPEESEET RLLNILGLIF KGPAASTQEK NPRESTGNMV TGQTVCKNKP
   601  NMSDPEESRG NDELVKQEML VQYLQDAYSF SRKITEAIGI ISKMMYENTT TVVQEVIEFF
   661  VMVFQFGVPQ ALFGVRRMLP LIWSKEPGVR EAVLNAYRQL YLNPKGDSAR AKAQALIQNL
   721  SLLLVDASVG TIQCLEEILC EFVQKDELKP AVTQLLWERA TEKVACCPLE RCSSVMLLGM
   781  MARGKPEIVG SNLDTLVSIG LDEKFPQDYR LAQQVCHAIA NISDRRKPSL GKRHPPFRLP
   841  QEHRLFERLR ETVTKGFVHP DPLWIPFKEV AVTLIYQLAE GPEVICAQIL QGCAKQALEK
   901  LEEKRTSQED PKESPAMLPT FLLMNLLSLA GDVALQQLVH LEQAVSGELC RRRVLREEQE
   961  HKTKDPKEKN TSSETTMEEE LGLVGATADD TEAELIRGIC EMELLDGKQT LAAFVPLLLK
  1021  VCNNPGLYSN PDLSAAASLA LGKFCMISAT FCDSQLRLLF TMLEKSPLPI VRSNLMVATG
  1081  DLAIRFPNLV DPWTPHLYAR LRDPAQQVRK TAGLVMTHLI LKDMVKVKGQ VSEMAVLLID
  1141  PEPQIAALAK NFFNELSHKG NAIYNLLPDI ISRLSDPELG VEEEPFHTIM KQLLSYITKD
  1201  KQTESLVEKL CQRFRTSRTE RQQRDLAYCV SQLPLTERGL RKMLDNFDCF GDKLSDESIF
  1261  SAFLSVVGKL RRGAKPEGKA IIDEFEQKLR ACHTRGLDGI KELEIGQAGS QRAPSAKKPS
  1321  TGSRYQPLAS TASDNDFVTP EPRRTTRRHP NTQQRASKKK PKVVFSSDES SEEDLSAEMT
  1381  EDETPKKTTP ILRASARRHR S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCAPD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

thymus: 72 nTPM
tonsil: 42 nTPM
lymph node: 36 nTPM
bone marrow: 34 nTPM
skin: 21 nTPM
appendix: 20 nTPM

Single-cell type

monocyte progenitors: 159 nCPM
neutrophil progenitors: 127 nCPM
erythrocyte progenitors: 108 nCPM
megakaryocyte progenitors: 78 nCPM
late spermatids: 53 nCPM
enteric transient amplifying cells: 43 nCPM

Immune cell

basophil: 11 nTPM
T-reg: 8.2 nTPM
NK-cell: 8.1 nTPM
naive CD8 T-cell: 7.3 nTPM
memory CD8 T-cell: 7.2 nTPM
naive CD4 T-cell: 7.2 nTPM

Brain region

white matter: 26 nTPM
medulla oblongata: 22 nTPM
basal ganglia: 21 nTPM
thalamus: 19 nTPM
midbrain: 19 nTPM
cerebellum: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NCAPD2.

Disease | AllUniProt

Conditions NCAPD2 is implicated in, by any mechanism.

Microcephaly 21, primary, autosomal recessive (MCPH21) MIM:617983

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 331 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Microcephaly 21, primary, autosomal recessive

Disease | ImmuneIEDB

Conditions an epitope on NCAPD2 was assayed in.

human immunodeficiency virus infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: -1.47
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

histone binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
Condensin subunit 1/Condensin-2 complex subunit D3
Condensin complex subunit 1, C-terminal
non-SMC mitotic condensation complex subunit 1
Condensin subunit 1
Condensin complex subunit 1, N-terminal
non-SMC mitotic condensation complex subunit 1, N-term

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NCAPD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCAPD2 as an antibody target. Whether an autoantibody or antibody against NCAPD2 could matter depends on whether native NCAPD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCAPD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCAPD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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