Seroatlas · Human Serome Atlas

SHTN1

Shootin-1

Also known as: KIAA1598, shootin-1, shootin1, SHOT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0MZ66
Gene
SHTN1
Ensembl
ENSG00000187164
Chromosome
10
Canonical length
631 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. Involved in positive regulation of neuron migration. Located in cytoplasm and microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

631 residues, UniProt reviewed canonical sequence.

>A0MZ66|SHTN1
     1  MNSSDEEKQL QLITSLKEQA IGEYEDLRAE NQKTKEKCDK IRQERDEAVK KLEEFQKISH
    61  MVIEEVNFMQ NHLEIEKTCR ESAEALATKL NKENKTLKRI SMLYMAKLGP DVITEEINID
   121  DEDSTTDTDG AAETCVSVQC QKQIKELRDQ IVSVQEEKKI LAIELENLKS KLVEVIEEVN
   181  KVKQEKTVLN SEVLEQRKVL EKCNRVSMLA VEEYEEMQVN LELEKDLRKK AESFAQEMFI
   241  EQNKLKRQSH LLLQSSIPDQ QLLKALDENA KLTQQLEEER IQHQQKVKEL EEQLENETLH
   301  KEIHNLKQQL ELLEEDKKEL ELKYQNSEEK ARNLKHSVDE LQKRVNQSEN SVPPPPPPPP
   361  PLPPPPPNPI RSLMSMIRKR SHPSGSGAKK EKATQPETTE EVTDLKRQAV EEMMDRIKKG
   421  VHLRPVNQTA RPKTKPESSK GCESAVDELK GILGTLNKST SSRSLKSLDP ENSETELERI
   481  LRRRKVTAEA DSSSPTGILA TSESKSMPVL GSVSSVTKTA LNKKTLEAEF NSPSPPTPEP
   541  GEGPRKLEGC TSSKVTFQPP SSIGCRKKYI DGEKQAEPVV VLDPVSTHEP QTKDQVAEKD
   601  PTQHKEDEGE IQPENKEDSI ENVRETDSSN C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHTN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
53 nTPM

Expression across tissuesHPA

Tissue

  • midbrain: 53 nTPM
  • spinal cord: 51 nTPM
  • hippocampal formation: 39 nTPM
  • amygdala: 36 nTPM
  • basal ganglia: 34 nTPM
  • hypothalamus: 26 nTPM

Single-cell type

  • oligodendrocytes: 1,442 nCPM
  • microglia: 708 nCPM
  • gonadotrophs: 591 nCPM
  • choroid plexus epithelial cells: 524 nCPM
  • lactotrophs: 499 nCPM
  • somatotrophs: 477 nCPM

Immune cell

  • classical monocyte: 20 nTPM
  • myeloid DC: 19 nTPM
  • intermediate monocyte: 13 nTPM
  • plasmacytoid DC: 13 nTPM
  • non-classical monocyte: 6.6 nTPM
  • total PBMC: 5.6 nTPM

Brain region

  • white matter: 283 nTPM
  • basal ganglia: 216 nTPM
  • thalamus: 184 nTPM
  • medulla oblongata: 184 nTPM
  • hypothalamus: 172 nTPM
  • midbrain: 166 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.04
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Shootin-1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SHTN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHTN1 as an antibody target. Whether an autoantibody or antibody against SHTN1 could matter depends on whether native SHTN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHTN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHTN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SHTN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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