Seroatlas · Human Serome Atlas

TPD52L2

Tumor protein D54

Also known as: D54, hD54, TPD54, TPD54_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43399
Gene
TPD52L2
Ensembl
ENSG00000101150
Chromosome
20
Canonical length
206 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. Expression of this gene may be a marker for breast cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>O43399|TPD52L2
     1  MDSAGQDINL NSPNKGLLSD SMTDVPVDTG VAARTPAVEG LTEAEEEELR AELTKVEEEI
    61  VTLRQVLAAK ERHCGELKRR LGLSTLGELK QNLSRSWHDV QVSSAYVKTS EKLGEWNEKV
   121  TQSDLYKKTQ ETLSQAGQKT SAALSTVGSA ISRKLGDMRN SATFKSFEDR VGTIKSKVVG
   181  DRENGSDNLP SSAGSGDKPL SDPAPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPD52L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
107 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 107 nTPM
  • esophagus: 107 nTPM
  • bone marrow: 93 nTPM
  • adrenal gland: 82 nTPM
  • heart muscle: 81 nTPM
  • adipose tissue: 81 nTPM

Single-cell type

  • astrocytes: 48 nCPM
  • ependymal cells: 39 nCPM
  • oligodendrocytes: 39 nCPM
  • bergmann glia: 36 nCPM
  • distal convoluted tubule cells: 35 nCPM
  • other brain neurons: 35 nCPM

Immune cell

  • neutrophil: 138 nTPM
  • total PBMC: 75 nTPM
  • classical monocyte: 73 nTPM
  • basophil: 67 nTPM
  • intermediate monocyte: 55 nTPM
  • non-classical monocyte: 48 nTPM

Brain region

  • thalamus: 68 nTPM
  • hypothalamus: 61 nTPM
  • white matter: 61 nTPM
  • medulla oblongata: 60 nTPM
  • pons: 58 nTPM
  • cerebral cortex: 56 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TPD52L2.

Disease | ImmuneIEDB

Conditions an epitope on TPD52L2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
-0.01
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TPD52L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPD52L2 as an antibody target. Whether an autoantibody or antibody against TPD52L2 could matter depends on whether native TPD52L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPD52L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPD52L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TPD52L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...