Seroatlas · Human Serome Atlas

CD244

Natural killer cell receptor 2B4

Also known as: 2B4, CD244_HUMAN, NAIL, NKR2B4, Nmrk, SLAMF4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BZW8
Gene
CD244
Ensembl
ENSG00000122223
Chromosome
1
Canonical length
370 aa
Protein class
CD markers, Human disease related genes, Plasma proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>Q9BZW8|CD244
     1  MLGQVVTLIL LLLLKVYQGK GCQGSADHVV SISGVPLQLQ PNSIQTKVDS IAWKKLLPSQ
    61  NGFHHILKWE NGSLPSNTSN DRFSFIVKNL SLLIKAAQQQ DSGLYCLEVT SISGKVQTAT
   121  FQVFVFESLL PDKVEKPRLQ GQGKILDRGR CQVALSCLVS RDGNVSYAWY RGSKLIQTAG
   181  NLTYLDEEVD INGTHTYTCN VSNPVSWESH TLNLTQDCQN AHQEFRFWPF LVIIVILSAL
   241  FLGTLACFCV WRRKRKEKQS ETSPKEFLTI YEDVKDLKTR RNHEQEQTFP GGGSTIYSMI
   301  QSQSSAPTSQ EPAYTLYSLI QPSRKSGSRK RNHSPSFNST IYEVIGKSQP KAQNPARLSR
   361  KELENFDVYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD244 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 16 nTPM
  • bone marrow: 9.4 nTPM
  • liver: 3.9 nTPM
  • appendix: 3.5 nTPM
  • lymph node: 3.2 nTPM
  • lung: 3.1 nTPM

Single-cell type

  • nk-cells: 76 nCPM
  • hematopoietic stem cells: 34 nCPM
  • kupffer cells: 34 nCPM
  • thymocytes: 27 nCPM
  • t-cells: 23 nCPM
  • monocytes: 19 nCPM

Immune cell

  • basophil: 474 nTPM
  • eosinophil: 108 nTPM
  • NK-cell: 79 nTPM
  • non-classical monocyte: 74 nTPM
  • gdT-cell: 72 nTPM
  • total PBMC: 71 nTPM

Brain region

  • cerebral cortex: 0.5 nTPM
  • medulla oblongata: 0.5 nTPM
  • white matter: 0.4 nTPM
  • midbrain: 0.3 nTPM
  • pons: 0.3 nTPM
  • spinal cord: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0.06
gnomAD missense Z
0.3
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD244 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD244 as an antibody target. Whether an autoantibody or antibody against CD244 could matter depends on whether native CD244 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD244 is annotated at the cell surface, where native CD244 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD244 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD244. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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