Seroatlas · Human Serome Atlas

SNX20

Sorting nexin-20

Also known as: SLIC-1, SLIC1, SNX20_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z614
Gene: SNX20
Ensembl: ENSG00000167208
Chromosome: 16
Canonical length: 316 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

SNX20 interacts with the cytoplasmic domain of PSGL1 (SELPLG; MIM 600738) and cycles PSGL1 into endosomes.[supplied by OMIM, Feb 2010]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>Q7Z614|SNX20
     1  MASPEHPGSP GCMGPITQCT ARTQQEAPAT GPDLPHPGPD GHLDTHSGLS SNSSMTTREL
    61  QQYWQNQKCR WKHVKLLFEI ASARIEERKV SKFVVYQIIV IQTGSFDNNK AVLERRYSDF
   121  AKLQKALLKT FREEIEDVEF PRKHLTGNFA EEMICERRRA LQEYLGLLYA IRCVRRSREF
   181  LDFLTRPELR EAFGCLRAGQ YPRALELLLR VLPLQEKLTA HCPAAAVPAL CAVLLCHRDL
   241  DRPAEAFAAG ERALQRLQAR EGHRYYAPLL DAMVRLAYAL GKDFVTLQER LEESQLRRPT
   301  PRGITLKELT VREYLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

thymus: 31 nTPM
lymph node: 26 nTPM
tonsil: 25 nTPM
spleen: 18 nTPM
appendix: 18 nTPM
bone marrow: 15 nTPM

Single-cell type

neutrophils: 66 nCPM
cdc: 34 nCPM
monocytes: 32 nCPM
neutrophil progenitors: 31 nCPM
pdcs: 29 nCPM
monocyte progenitors: 27 nCPM

Immune cell

basophil: 307 nTPM
eosinophil: 205 nTPM
non-classical monocyte: 148 nTPM
T-reg: 138 nTPM
myeloid DC: 124 nTPM
intermediate monocyte: 118 nTPM

Brain region

medulla oblongata: 7.4 nTPM
white matter: 6.3 nTPM
thalamus: 6 nTPM
pons: 5.3 nTPM
midbrain: 4.7 nTPM
spinal cord: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: 1.01
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SELPLG

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX20 as an antibody target. Whether an autoantibody or antibody against SNX20 could matter depends on whether native SNX20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX20 is annotated at the cell surface, where native SNX20 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SNX20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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