Seroatlas · Human Serome Atlas

HAVCR1

Hepatitis A virus cellular receptor 1

Also known as: CD365, HAVCR, HAVCR-1, HAVR1_HUMAN, KIM1, TIM-1, TIM1, TIMD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96D42
Gene: HAVCR1
Ensembl: ENSG00000113249
Chromosome: 5
Canonical length: 364 aa
Protein class: CD markers, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. The protein is a receptor for multiple other viruses, including Ebola virus, Marburg virus, Dengue virus, and Zika virus and is a possible entry factor for SARS-CoV-2 and other coronaviruses. [provided by RefSeq, Sep 2021]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q96D42|HAVCR1
     1  MHPQVVILSL ILHLADSVAG SVKVGGEAGP SVTLPCHYSG AVTSMCWNRG SCSLFTCQNG
    61  IVWTNGTHVT YRKDTRYKLL GDLSRRDVSL TIENTAVSDS GVYCCRVEHR GWFNDMKITV
   121  SLEIVPPKVT TTPIVTTVPT VTTVRTSTTV PTTTTVPMTT VPTTTVPTTM SIPTTTTVLT
   181  TMTVSTTTSV PTTTSIPTTT SVPVTTTVST FVPPMPLPRQ NHEPVATSPS SPQPAETHPT
   241  TLQGAIRREP TSSPLYSYTT DGNDTVTESS DGLWNNNQTQ LFLEHSLLTA NTTKGIYAGV
   301  CISVLVLLAL LGVIIAKKYF FKKEVQQLSV SFSSLQIKAL QNAVEKEVQA EDNIYIENSL
   361  YATD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HAVCR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 6.5 nTPM

Expression across tissuesHPA

Tissue

kidney: 6.5 nTPM
colon: 4.3 nTPM
rectum: 3.4 nTPM
testis: 0.9 nTPM
lymph node: 0.8 nTPM
bone marrow: 0.7 nTPM

Single-cell type

proximal tubule cells: 71 nCPM
loop of henle epithelial cells: 14 nCPM
nk-cells: 12 nCPM
colonocytes: 11 nCPM
cdc: 7.9 nCPM
macrophages: 7.7 nCPM

Immune cell

naive CD4 T-cell: 2.5 nTPM
T-reg: 2 nTPM
naive CD8 T-cell: 1.6 nTPM
memory CD4 T-cell: 1 nTPM
neutrophil: 0.8 nTPM
basophil: 0.6 nTPM

Brain region

white matter: 3.8 nTPM
cerebellum: 3.7 nTPM
hypothalamus: 3.3 nTPM
medulla oblongata: 3.3 nTPM
pons: 3.3 nTPM
thalamus: 3.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HAVCR1.

Disease | ImmuneIEDB

Conditions an epitope on HAVCR1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: -0.01
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Immunoglobulin/major histocompatibility complex, conserved site
Immunoglobulin domain subtype
Immunoglobulin-like domain
Immunoglobulin V-set domain
Immunoglobulin-like fold
Immunoglobulin-like domain superfamily
Immunoglobulin V-set domain
T-cell immunoglobulin and mucin domain-containing protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HAVCR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HAVCR1 as an antibody target. Whether an autoantibody or antibody against HAVCR1 could matter depends on whether native HAVCR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HAVCR1 is annotated at the cell surface, where native HAVCR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HAVCR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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