Seroatlas · Human Serome Atlas

CCDC148

Coiled-coil domain-containing protein 148

Also known as: CC148_HUMAN, MGC125588

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NFR7
Gene: CCDC148
Ensembl: ENSG00000153237
Chromosome: 2
Canonical length: 591 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

No narrative summary is available for CCDC148 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

591 residues, UniProt reviewed canonical sequence.

>Q8NFR7|CCDC148
     1  MCAASASPDN LVFHMKNEMR NIKYKPVDYQ QLRALTEAKK LASASAKLKI RKAMLTSKLS
    61  KEQTLIKQHK QVWWQEYQRL NEVRCKMESE IKSLLNEENI GNECLCDLTN FEQELSEQQC
   121  TYLKNVINPI QQLRADLKYR QHHTLQHSHP HIEFNSMKVL EEVDFVKKQL KTVFERLRLE
   181  QQRIENDLSD WSIKILDHSL EEKTNPLSEL PIELESLECP YPDLKSSILS EFYKFTQKYQ
   241  KKLQDFNLQL EDIYRNCQLS EEDHWIYQAI LDQYPGDLFG RRTLYLDMLQ RYFPHKSRHD
   301  LVEHEKYCDQ YRFAIEQQNI LISNWNKNKK DFIQKAVLTL TEACATHEME SMLAKDKKKQ
   361  QELCADLKAK VRQWRAHQEE VARLEMEISA RRREKEEEKE KLWKKKELLQ RAEKKKKIKK
   421  YWAKKKQKWQ EMEMRDLQRL EELKKLIAEQ SLKDRERVKY RQELLERRLM EKKEVALQEA
   481  HEDKERARRL EALRKQVAVV AQFDPVRMMS DTMASKARMG IEIEEEFILQ KPLFTLNTYN
   541  EQQIISDPRL RFELALREAG LHRTLYAKEI LPKISPQKPP RKDMESTVFK I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC148 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 4.6 nTPM

Expression across tissuesHPA

Tissue

testis: 4.6 nTPM
parathyroid gland: 3 nTPM
kidney: 2.9 nTPM
choroid plexus: 2.8 nTPM
fallopian tube: 2.5 nTPM
retina: 2.4 nTPM

Single-cell type

distal convoluted tubule cells: 501 nCPM
loop of henle epithelial cells: 389 nCPM
podocytes: 294 nCPM
respiratory ciliated cells: 281 nCPM
ependymal cells: 256 nCPM
choroid plexus epithelial cells: 255 nCPM

Immune cell

basophil: 0.3 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 13 nTPM
cerebellum: 5.2 nTPM
medulla oblongata: 4.6 nTPM
midbrain: 4.3 nTPM
basal ganglia: 4 nTPM
cerebral cortex: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: -0.74
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein CCDC148/CCDC112

KeywordsUniProt

Coiled coil

InteractionsUniProt · HPA

Protein binding partners of CCDC148 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SAT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC148 as an antibody target. Whether an autoantibody or antibody against CCDC148 could matter depends on whether native CCDC148 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC148 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC148 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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