Seroatlas · Human Serome Atlas

HOXB9

Homeobox protein Hox-B9

Also known as: HOX2, HOX2E, HXB9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17482
Gene: HOXB9
Ensembl: ENSG00000170689
Chromosome: 17
Canonical length: 250 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>P17482|HOXB9
     1  MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYASSRQPG HAEHLEFPSC SFQPKAPVFG
    61  ASWAPLSPHA SGSLPSVYHP YIQPQGVPPA ESRYLRTWLE PAPRGEAAPG QGQAAVKAEP
   121  LLGAPGELLK QGTPEYSLET SAGREAVLSN QRPGYGDNKI CEGSEDKERP DQTNPSANWL
   181  HARSSRKKRC PYTKYQTLEL EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM
   241  KKMNKEQGKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXB9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 83 nTPM

Expression across tissuesHPA

Tissue

epididymis: 83 nTPM
colon: 25 nTPM
kidney: 22 nTPM
rectum: 21 nTPM
seminal vesicle: 15 nTPM
small intestine: 13 nTPM

Single-cell type

epididymal principal cells: 12 nCPM
tuft cells: 12 nCPM
epididymal basal cells: 9.7 nCPM
epididymal efferent duct absorptive cells: 9.3 nCPM
endometrial secretory cells: 6.8 nCPM
neuroendocrine cells: 6.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

spinal cord: 6.1 nTPM
white matter: 1.6 nTPM
medulla oblongata: 0.2 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0.31
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HOXB9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOXB9 as an antibody target. Whether an autoantibody or antibody against HOXB9 could matter depends on whether native HOXB9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOXB9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOXB9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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