SLC67A1

Protein identityUniProt · HPA

UniProt accession

Q96BI1

Gene

SLC67A1

Ensembl

ENSG00000110628

Chromosome

11

Canonical length

424 aa

Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters

Subcellular location

Plasma membrane

OverviewNCBI Gene

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Several alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

424 residues, UniProt reviewed canonical sequence.

>Q96BI1|SLC67A1
     1  MQGARAPRDQ GRSPGRMSAL GRSSVILLTY VLAATELTCL FMQFSIVPYL SRKLGLDSIA
    61  FGYLQTTFGV LQLLGGPVFG RFADQRGARA ALTLSFLAAL ALYLLLAAAS SPALPGVYLL
   121  FASRLPGALM HTLPAAQMVI TDLSAPEERP AALGRLGLCF GVGVILGSLL GGTLVSAYGI
   181  QCPAILAALA TLLGAVLSFT CIPASTKGAK TDAQAPLPGG PRASVFDLKA IASLLRLPDV
   241  PRIFLVKVAS NCPTGLFMVM FSIISMDFFQ LEAAQAGYLM SFFGLLQMVT QGLVIGQLSS
   301  HFSEEVLLRA SVLVFIVVGL AMAWMSSVFH FCLLVPGLVF SLCTLNVVTD SMLIKAVSTS
   361  DTGTMLGLCA SVQPLLRTLG PTVGGLLYRS FGVPVFGHVQ VAINTLVLLV LWRKPMPQRK
   421  DKVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC67A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

10

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

81 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC67A1.

Disease | AllUniProt

Conditions SLC67A1 is implicated in, by any mechanism.

• Lung cancer (LNCR) MIM:211980
• Rhabdomyosarcoma, embryonal, 1 (RMSE1) MIM:268210

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.16

gnomAD pLI

0

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• organic cation transport
• xenobiotic detoxification by transmembrane export across the plasma membrane
• xenobiotic transport

Molecular functions

• ubiquitin protein ligase binding
• xenobiotic transmembrane transporter activity

Cellular components

• apical plasma membrane
• cytoplasm
• membrane
• nuclear envelope
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Tetracycline resistance protein TetA/multidrug resistance protein MdtG-like
• Major facilitator superfamily
• Major facilitator superfamily domain
• MFS transporter superfamily
• Major Facilitator Superfamily

KeywordsUniProt

• Cell membrane
• Membrane
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of SLC67A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RNF167
• SLC30A9