Seroatlas · Human Serome Atlas

INSIG2

Insulin-induced gene 2 protein

Also known as: INSI2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5U4
Gene: INSIG2
Ensembl: ENSG00000125629
Chromosome: 2
Canonical length: 225 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>Q9Y5U4|INSIG2
     1  MAEGETESPG PKKCGPYISS VTSQSVNLMI RGVVLFFIGV FLALVLNLLQ IQRNVTLFPP
    61  DVIASIFSSA WWVPPCCGTA SAVIGLLYPC IDRHLGEPHK FKREWSSVMR CVAVFVGINH
   121  ASAKVDFDNN IQLSLTLAAL SIGLWWTFDR SRSGFGLGVG IAFLATVVTQ LLVYNGVYQY
   181  TSPDFLYVRS WLPCIFFAGG ITMGNIGRQL AMYECKVIAE KSHQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INSIG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

liver: 21 nTPM
parathyroid gland: 9.8 nTPM
kidney: 9.3 nTPM
spleen: 8.6 nTPM
cerebral cortex: 8 nTPM
blood vessel: 7.9 nTPM

Single-cell type

pancreatic duct cells: 135 nCPM
pancreatic acinar cells: 126 nCPM
esophageal apical cells: 109 nCPM
gastric chief cells: 89 nCPM
alveolar cells type 1: 84 nCPM
parietal cells: 81 nCPM

Immune cell

eosinophil: 7.7 nTPM
non-classical monocyte: 7.4 nTPM
intermediate monocyte: 6 nTPM
naive CD8 T-cell: 5.9 nTPM
NK-cell: 5.9 nTPM
naive CD4 T-cell: 5.3 nTPM

Brain region

cerebellum: 16 nTPM
hippocampal formation: 15 nTPM
choroid plexus: 14 nTPM
thalamus: 14 nTPM
cerebral cortex: 14 nTPM
midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.06
gnomAD missense Z: 1.84
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INSIG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INSIG2 as an antibody target. Whether an autoantibody or antibody against INSIG2 could matter depends on whether native INSIG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INSIG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INSIG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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