Seroatlas · Human Serome Atlas

SREBF2

Sterol regulatory element-binding protein 2

Also known as: bHLHd2, SRBP2_HUMAN, SREBP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q12772
Gene
SREBF2
Ensembl
ENSG00000198911
Chromosome
22
Canonical length
1141 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Subcellular location
Nucleoplasm,Endoplasmic reticulum,Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

1141 residues, UniProt reviewed canonical sequence.

>Q12772|SREBF2
     1  MDDSGELGGL ETMETLTELG DELTLGDIDE MLQFVSNQVG EFPDLFSEQL CSSFPGSGGS
    61  GSSSGSSGSS SSSSNGRGSS SGAVDPSVQR SFTQVTLPSF SPSAASPQAP TLQVKVSPTS
   121  VPTTPRATPI LQPRPQPQPQ PQTQLQQQTV MITPTFSTTP QTRIIQQPLI YQNAATSFQV
   181  LQPQVQSLVT SSQVQPVTIQ QQVQTVQAQR VLTQTANGTL QTLAPATVQT VAAPQVQQVP
   241  VLVQPQIIKT DSLVLTTLKT DGSPVMAAVQ NPALTALTTP IQTAALQVPT LVGSSGTILT
   301  TMPVMMGQEK VPIKQVPGGV KQLEPPKEGE RRTTHNIIEK RYRSSINDKI IELKDLVMGT
   361  DAKMHKSGVL RKAIDYIKYL QQVNHKLRQE NMVLKLANQK NKLLKGIDLG SLVDNEVDLK
   421  IEDFNQNVLL MSPPASDSGS QAGFSPYSID SEPGSPLLDD AKVKDEPDSP PVALGMVDRS
   481  RILLCVLTFL CLSFNPLTSL LQWGGAHDSD QHPHSGSGRS VLSFESGSGG WFDWMMPTLL
   541  LWLVNGVIVL SVFVKLLVHG EPVIRPHSRS SVTFWRHRKQ ADLDLARGDF AAAAGNLQTC
   601  LAVLGRALPT SRLDLACSLS WNVIRYSLQK LRLVRWLLKK VFQCRRATPA TEAGFEDEAK
   661  TSARDAALAY HRLHQLHITG KLPAGSACSD VHMALCAVNL AECAEEKIPP STLVEIHLTA
   721  AMGLKTRCGG KLGFLASYFL SRAQSLCGPE HSAVPDSLRW LCHPLGQKFF MERSWSVKSA
   781  AKESLYCAQR NPADPIAQVH QAFCKNLLER AIESLVKPQA KKKAGDQEEE SCEFSSALEY
   841  LKLLHSFVDS VGVMSPPLSR SSVLKSALGP DIICRWWTSA ITVAISWLQG DDAAVRSHFT
   901  KVERIPKALE VTESPLVKAI FHACRAMHAS LPGKADGQQS SFCHCERASG HLWSSLNVSG
   961  ATSDPALNHV VQLLTCDLLL SLRTALWQKQ ASASQAVGET YHASGAELAG FQRDLGSLRR
  1021  LAHSFRPAYR KVFLHEATVR LMAGASPTRT HQLLEHSLRR RTTQSTKHGE VDAWPGQRER
  1081  ATAILLACRH LPLSFLSSPG QRAVLLAEAA RTLEKVGDRR SCNDCQQMIV KLGGGTAIAA
  1141  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SREBF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
88 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 88 nTPM
  • cerebellum: 87 nTPM
  • esophagus: 77 nTPM
  • adrenal gland: 76 nTPM
  • amygdala: 64 nTPM
  • epididymis: 57 nTPM

Single-cell type

  • adrenal cortex cells: 426 nCPM
  • retinal ganglion cells: 352 nCPM
  • retinal amacrine cells: 344 nCPM
  • urothelial cells: 320 nCPM
  • endometrial luminal cells: 316 nCPM
  • epididymal principal cells: 315 nCPM

Immune cell

  • memory B-cell: 7.1 nTPM
  • plasmacytoid DC: 6.3 nTPM
  • myeloid DC: 5 nTPM
  • naive B-cell: 4.8 nTPM
  • total PBMC: 4.8 nTPM
  • classical monocyte: 4.7 nTPM

Brain region

  • cerebral cortex: 202 nTPM
  • hippocampal formation: 187 nTPM
  • amygdala: 183 nTPM
  • white matter: 168 nTPM
  • basal ganglia: 163 nTPM
  • midbrain: 163 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.21
gnomAD missense Z
0.68
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SREBF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SREBF2 as an antibody target. Whether an autoantibody or antibody against SREBF2 could matter depends on whether native SREBF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SREBF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SREBF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SREBF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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