Seroatlas · Human Serome Atlas

RALGPS2

Ras-specific guanine nucleotide-releasing factor RalGPS2

Also known as: FLJ10244, FLJ25604, KIAA0351, RGPS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86X27
Gene
RALGPS2
Ensembl
ENSG00000116191
Chromosome
1
Canonical length
583 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

583 residues, UniProt reviewed canonical sequence.

>Q86X27|RALGPS2
     1  MDLMNGQASS VNIAATASEK SSSSESLSDK GSELKKSFDA VVFDVLKVTP EEYAGQITLM
    61  DVPVFKAIQP DELSSCGWNK KEKYSSAPNA VAFTRRFNHV SFWVVREILH AQTLKIRAEV
   121  LSHYIKTAKK LYELNNLHAL MAVVSGLQSA PIFRLTKTWA LLSRKDKTTF EKLEYVMSKE
   181  DNYKRLRDYI SSLKMTPCIP YLGIYLSDLT YIDSAYPSTG SILENEQRSN LMNNILRIIS
   241  DLQQSCEYDI PMLPHVQKYL NSVQYIEELQ KFVEDDNYKL SLKIEPGTST PRSAASREDL
   301  VGPEVGASPQ SGRKSVAAEG ALLPQTPPSP RNLIPHGHRK CHSLGYNFIH KMNTAEFKSA
   361  TFPNAGPRHL LDDSVMEPHA PSRGQAESST LSSGISIGSS DGSELSEETS WPAFERNRLY
   421  HSLGPVTRVA RNGYRSHMKA SSSAESEDLA VHLYPGAVTI QGVLRRKTLL KEGKKPTVAS
   481  WTKYWAALCG TQLFYYAAKS LKATERKHFK STSNKNVSVI GWMVMMADDP EHPDLFLLTD
   541  SEKGNSYKFQ AGNRMNAMLW FKHLSAACQS NKQQVPTNLM TFE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RALGPS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • testis: 67 nTPM
  • retina: 50 nTPM
  • tonsil: 49 nTPM
  • lymph node: 43 nTPM
  • liver: 28 nTPM
  • spleen: 26 nTPM

Single-cell type

  • b-cells: 1,378 nCPM
  • rod photoreceptor cells: 824 nCPM
  • urothelial cells: 632 nCPM
  • plasma cells: 514 nCPM
  • esophageal apical cells: 483 nCPM
  • cone photoreceptor cells: 458 nCPM

Immune cell

  • memory B-cell: 29 nTPM
  • naive B-cell: 24 nTPM
  • eosinophil: 2.5 nTPM
  • neutrophil: 1.4 nTPM
  • total PBMC: 1.2 nTPM
  • naive CD4 T-cell: 0.9 nTPM

Brain region

  • hippocampal formation: 20 nTPM
  • hypothalamus: 17 nTPM
  • basal ganglia: 15 nTPM
  • cerebellum: 15 nTPM
  • cerebral cortex: 15 nTPM
  • spinal cord: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.26
gnomAD missense Z
2.14
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RALGPS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RALGPS2 as an antibody target. Whether an autoantibody or antibody against RALGPS2 could matter depends on whether native RALGPS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RALGPS2 is annotated at the cell surface, where native RALGPS2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RALGPS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RALGPS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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