Seroatlas · Human Serome Atlas

RAD9B

Cell cycle checkpoint control protein RAD9B

Also known as: FLJ40346, RAD9B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6WBX8
Gene: RAD9B
Ensembl: ENSG00000151164
Chromosome: 12
Canonical length: 426 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in DNA integrity checkpoint signaling; DNA repair; and cellular response to ionizing radiation. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>Q6WBX8|RAD9B
     1  MLKCVMSGSQ VKVFGKAVQA LSRISDEFWL DPSKKGLALR CVNSSRSAYG CVLFSPVFFQ
    61  HYQWSALVKM SENELDTTLH LKCKLGMKSI LPIFRCLNSL ERNIEKCRIF TRSDKCKVVI
   121  QFFYRHGIKR THNICFQESQ PLQVIFDKNV CTNTLMIQPR LLADAIVLFT SSQEEVTLAV
   181  TPLNFCLKSS NEESMDLSNA VHSEMFVGSD EFDFFQIGMD TEITFCFKEL KGILTFSEAT
   241  HAPISIYFDF PGKPLALSID DMLVEANFIL ATLADEQSRA SSPQSLCLSQ KRKRSDLIEK
   301  KAGKNVTGQA LECISKKAAP RRLYPKETLT NISALENCGS PAMKRVDGDV SEVSESSVSN
   361  TEEVPGSLCL RKFSCMFFGA VSSDQQEHFN HPFDSLARAS DSEEDMNNVC CRKEFNGSDA
   421  KYFCII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAD9B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
spinal cord: 0.9 nTPM
heart muscle: 0.8 nTPM
skeletal muscle: 0.8 nTPM
midbrain: 0.7 nTPM
ovary: 0.7 nTPM

Single-cell type

early primary spermatocytes: 190 nCPM
cardiomyocytes: 39 nCPM
late primary spermatocytes: 20 nCPM
myonuclei: 19 nCPM
undifferentiated spermatogonia: 18 nCPM
differentiating spermatogonia: 17 nCPM

Immune cell

basophil: 4.7 nTPM
myeloid DC: 0.9 nTPM
non-classical monocyte: 0.9 nTPM
classical monocyte: 0.5 nTPM
plasmacytoid DC: 0.5 nTPM
intermediate monocyte: 0.4 nTPM

Brain region

white matter: 1.5 nTPM
medulla oblongata: 1 nTPM
basal ganglia: 0.9 nTPM
cerebellum: 0.9 nTPM
pons: 0.9 nTPM
thalamus: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAD9B.

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 68 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neural tube defect

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 0.32
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of RAD9B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAD9B as an antibody target. Whether an autoantibody or antibody against RAD9B could matter depends on whether native RAD9B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAD9B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAD9B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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