Seroatlas · Human Serome Atlas

HUS1B

Checkpoint protein HUS1B

Also known as: HUS1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHY5
Gene: HUS1B
Ensembl: ENSG00000188996
Chromosome: 6
Canonical length: 278 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>Q8NHY5|HUS1B
     1  MKFRAKITGK GCLELFIHVS GTVARLAKVC VLRVRPDSLC FGPAGSGGLH EARLWCEVRQ
    61  GAFQQFRMEG VSEDLDEIHL ELTAEHLSRA ARSAAGASSL KLQLTHKRRP SLTVAVELVS
   121  SLGRARSVVH DLPVRVLPRR VWRDCLPPSL RASDASIRLP RWRTLRSIVE RMANVGSHVL
   181  VEANLSGRMT LSIETEVVSI QSYFKNLGNP PQSAVGVPEN RDLESMVQVR VDNRKLLQFL
   241  EGQQIHPTTA LCNIWDNTLL QLVLVQEDVS LQYFIPAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HUS1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 2 nTPM

Expression across tissuesHPA

Tissue

testis: 2 nTPM
prostate: 0.7 nTPM
bone marrow: 0.6 nTPM
cervix: 0.6 nTPM
lung: 0.6 nTPM
skin: 0.6 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

naive CD8 T-cell: 0.3 nTPM
memory B-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

choroid plexus: 2.4 nTPM
white matter: 2.4 nTPM
cerebral cortex: 2.3 nTPM
medulla oblongata: 2.3 nTPM
amygdala: 2.2 nTPM
pons: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.45
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of HUS1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HUS1B as an antibody target. Whether an autoantibody or antibody against HUS1B could matter depends on whether native HUS1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HUS1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HUS1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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