GPR89B
Golgi pH regulator B
Also known as: GPHRB_HUMAN, GPR89, GPR89C, SH120
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0CG08
- Gene
- GPR89B
- Ensembl
- ENSG00000188092
- Chromosome
- 1
- Canonical length
- 455 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Endoplasmic reticulum
- Quaternary structure
- Homotrimer
OverviewNCBI Gene
Enables voltage-gated monoatomic anion channel activity. Involved in intracellular pH reduction. Located in Golgi cisterna membrane and Golgi-associated vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
455 residues, UniProt reviewed canonical sequence.
>P0CG08|GPR89B
1 MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEIRQYVV QVIFSVTFAF SCTMFELIIF
61 EILGVLNSSS RYFHWKMNLC VILLILVFMV PFYIGYFIVS NIRLLHKQRL LFSCLLWLTF
121 MYFFWKLGDP FPILSPKHGI LSIEQLISRV GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN
181 VTDTDILALE RRLLQTMDMI ISKKKRMAMA RRTMFQKGEV HNKPSGFWGM IKSVTTSASG
241 SENLTLIQQE VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK
301 IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI IIVTSIRGLL
361 ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM SMPLEYRTII TEVLGELQFN
421 FYHRWFDVIF LVSALSSILF LYLAHKQAPE KQMAPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GPR89B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 9
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 12 nTPM
Expression across tissuesHPA
Tissue
- kidney: 12 nTPM
- pancreas: 6.6 nTPM
- tongue: 5.6 nTPM
- liver: 5.4 nTPM
- stomach: 5 nTPM
- testis: 4.9 nTPM
Single-cell type
- tuft cells: 185 nCPM
- proximal tubule cells: 61 nCPM
- thymocytes: 58 nCPM
- enterocytes: 57 nCPM
- nk-cells: 56 nCPM
- t-cells: 49 nCPM
Immune cell
- NK-cell: 4.4 nTPM
- basophil: 3.5 nTPM
- MAIT T-cell: 3.3 nTPM
- memory CD4 T-cell: 3.2 nTPM
- naive CD4 T-cell: 3.1 nTPM
- naive B-cell: 3 nTPM
Brain region
- pons: 18 nTPM
- cerebral cortex: 17 nTPM
- medulla oblongata: 17 nTPM
- cerebellum: 16 nTPM
- white matter: 15 nTPM
- midbrain: 14 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.24
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.81
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of GPR89B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GPR89B as an antibody target. Whether an autoantibody or antibody against GPR89B could matter depends on whether native GPR89B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GPR89B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GPR89B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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