Seroatlas · Human Serome Atlas

GPR89A

Golgi pH regulator A

Also known as: GPHRA_HUMAN, UNQ192

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B7ZAQ6
Gene: GPR89A
Ensembl: ENSG00000117262
Chromosome: 1
Canonical length: 455 aa
Protein class: Predicted membrane proteins
Subcellular location: Endoplasmic reticulum
Quaternary structure: Homotrimer

OverviewNCBI Gene

Enables voltage-gated monoatomic anion channel activity. Involved in intracellular pH reduction. Located in Golgi cisterna membrane and Golgi-associated vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

455 residues, UniProt reviewed canonical sequence.

>B7ZAQ6|GPR89A
     1  MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEIRQYVV QVIFSVTFAF SCTMFELIIF
    61  EILGVLNSSS RYFHWKMNLC VILLILVFMV PFYIGYFIVS NIRLLHKQRL LFSCLLWLTF
   121  MYFFWKLGDP FPILSPKHGI LSIEQLISRV GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN
   181  VTDTDILALE RRLLQTMDMI ISKKKRMAMA RRTMFQKGEV HNKPSGFWGM IKSVTTSASG
   241  SENLTLIQQE VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK
   301  IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI IIVTSIRGLL
   361  ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM SMPLEYRTII TEVLGELQFN
   421  FYHRWFDVIF LVSALSSILF LYLAHKQAPE KQMAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR89A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

kidney: 29 nTPM
liver: 23 nTPM
testis: 14 nTPM
breast: 13 nTPM
pancreas: 11 nTPM
cervix: 11 nTPM

Single-cell type

tuft cells: 173 nCPM
somatotrophs: 63 nCPM
early primary spermatocytes: 56 nCPM
erythrocyte progenitors: 52 nCPM
enterocytes: 49 nCPM
extravillous trophoblasts: 45 nCPM

Immune cell

memory CD8 T-cell: 9.9 nTPM
MAIT T-cell: 9.5 nTPM
NK-cell: 9.3 nTPM
gdT-cell: 9.2 nTPM
T-reg: 8.3 nTPM
myeloid DC: 8.1 nTPM

Brain region

cerebellum: 12 nTPM
pons: 12 nTPM
midbrain: 10 nTPM
hypothalamus: 9.8 nTPM
medulla oblongata: 9.6 nTPM
cerebral cortex: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: 0.34

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

voltage-gated monoatomic anion channel activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR89A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RABL3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR89A as an antibody target. Whether an autoantibody or antibody against GPR89A could matter depends on whether native GPR89A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR89A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPR89A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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