Seroatlas · Human Serome Atlas

RIN3

Ras and Rab interactor 3

Also known as: FLJ22439, RIN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TB24
Gene: RIN3
Ensembl: ENSG00000100599
Chromosome: 14
Canonical length: 985 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

985 residues, UniProt reviewed canonical sequence.

>Q8TB24|RIN3
     1  MIRHAGAPAR GDPTGPVPVV GKGEEEEEED GMRLCLPANP KNCLPHRRGI SILEKLIKTC
    61  PVWLQLSLGQ AEVARILHRV VAGMFLVRRD SSSKQLVLCV HFPSLNESSA EVLEYTIKEE
   121  KSILYLEGSA LVFEDIFRLI AFYCVSRDLL PFTLRLPQAI LEASSFTDLE TIANLGLGFW
   181  DSSLNPPQER GKPAEPPRDR APGFPLVSSL RPTAHDANCA CEIELSVGND RLWFVNPIFI
   241  EDCSSALPTD QPPLGNCPAR PLPPTSDATS PTSRWAPRRP PPPPPVLPLQ PCSPAQPPVL
   301  PALAPAPACP LPTSPPVPAP HVTPHAPGPP DHPNQPPMMT CERLPCPTAG LGPLREEAMK
   361  PGAASSPLQQ VPAPPLPAKK NLPTAPPRRR VSERVSLEDQ SPGMAAEGDQ LSLPPQGTSD
   421  GPEDTPREST EQGQDTEVKA SDPHSMPELP RTAKQPPVPP PRKKRISRQL ASTLPAPLEN
   481  AELCTQAMAL ETPTPGPPRE GQSPASQAGT QHPPAQATAH SQSSPEFKGS LASLSDSLGV
   541  SVMATDQDSY STSSTEEELE QFSSPSVKKK PSMILGKARH RLSFASFSSM FHAFLSNNRK
   601  LYKKVVELAQ DKGSYFGSLV QDYKVYSLEM MARQTSSTEM LQEIRTMMTQ LKSYLLQSTE
   661  LKALVDPALH SEEELEAIVE SALYKCVLKP LKEAINSCLH QIHSKDGSLQ QLKENQLVIL
   721  ATTTTDLGVT TSVPEVPMME KILQKFTSMH KAYSPEKKIS ILLKTCKLIY DSMALGNPGK
   781  PYGADDFLPV LMYVLARSNL TEMLLNVEYM MELMDPALQL GEGSYYLTTT YGALEHIKSY
   841  DKITVTRQLS VEVQDSIHRW ERRRTLNKAR ASRSSVQDFI CVSYLEPEQQ ARTLASRADT
   901  QAQALCAQCA EKFAVERPQA HRLFVLVDGR CFQLADDALP HCIKGYLLRS EPKRDFHFVY
   961  RPLDGGGGGG GGSPPCLVVR EPNFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 44 nTPM
spleen: 22 nTPM
colon: 17 nTPM
blood vessel: 16 nTPM
lung: 15 nTPM
adrenal gland: 13 nTPM

Single-cell type

neutrophils: 627 nCPM
monocytes: 538 nCPM
neutrophil progenitors: 505 nCPM
microglia: 424 nCPM
kupffer cells: 347 nCPM
nk-cells: 322 nCPM

Immune cell

eosinophil: 54 nTPM
non-classical monocyte: 51 nTPM
classical monocyte: 44 nTPM
myeloid DC: 42 nTPM
intermediate monocyte: 40 nTPM
neutrophil: 40 nTPM

Brain region

medulla oblongata: 27 nTPM
thalamus: 26 nTPM
white matter: 24 nTPM
spinal cord: 22 nTPM
pons: 21 nTPM
hypothalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.77
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

endocytosis
negative regulation of receptor internalization
regulation of vesicle size
signal transduction
negative regulation of mast cell chemotaxis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ras-associating domain
SH2 domain
VPS9 domain
SH2 domain superfamily
VPS9 domain superfamily
Vacuolar protein sorting-associated protein 9-like
Vacuolar sorting protein 9 (VPS9) domain
RIN1-like domain
Ras and Rab interactor 3, SH2 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIN3 as an antibody target. Whether an autoantibody or antibody against RIN3 could matter depends on whether native RIN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...