Seroatlas · Human Serome Atlas

R3HDM1

R3H domain-containing protein 1

Also known as: KIAA0029, R3HD1_HUMAN, R3HDM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15032
Gene: R3HDM1
Ensembl: ENSG00000048991
Chromosome: 2
Canonical length: 1099 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1099 residues, UniProt reviewed canonical sequence.

>Q15032|R3HDM1
     1  MRMSDTVTVK DETATMKDLE AEVKDTTRVE NLIKSENYGK ILVEKNEHCI ENNIDLQRPL
    61  QSFGQTGKRS KSSSKLKLVR SLAVCEESPP PPAPEISQEN QEKIQIQLTQ SFEKEEKPSK
   121  DEAEKEKASD KLPRKMLSRD SSQEYTDSTG IDLHEFLVNT LKNNPRDRMM LLKLEQEILD
   181  FIGNNESPRK KFPPMTSYHR MLLHRVAAYF GLDHNVDQSG KSVIVNKTSN TRIPDQKFNE
   241  HIKDDKGEDF QKRYILKRDN SSFDKDDNQM RIRLKDDRRS KSIEEREEEY QRARDRIFSQ
   301  DSLCSQENYI IDKRLQDEDA SSTQQRRQIF RVNKDASGRS TNSHQSSTEN ELKYSEPRPW
   361  SSTDSDSSLR NLKPAVTKAS SFSGISVLTR GDSSGSSKSI GRLSKTGSES SGSVGSSTGS
   421  LSHIQQPLPG TALSQSSHGA PVVYPTVSTH SSLSFDGGLN GQVASPSTSF FLLPLEAAGI
   481  PPGSILINPQ TGQPFINPDG SPVVYNPPMT QQPVRSQVPG PPQPPLPAPP QQPAANHIFS
   541  QDNLGSQFSH MSLARQPSAD GSDPHAAMFQ STVVLQSPQQ SGYIMTAAPP PHPPPPPPPP
   601  PPPPPLPPGQ PVPTAGYPAS GHPVSQPVLQ QQGYIQQPSP QMPACYCAPG HYHSSQPQYR
   661  PVPSVHYNSH LNQPLPQPAQ QTGYQVIPNQ QQNYQGIVGV QQPQSQSLVS GQPNSIGNQI
   721  QGVVIPYTSV PTYQVSLPQG SQGIPHQTYQ QPVMFPNQSN QGSMPTTGMP VYYSVIPPGQ
   781  QNNLSSSVGY LQHPGSEQVQ FPRTTSPCSS QQLQGHQCTA GPPPPPGGGM VMMQLSVPNN
   841  PQSCAHSPPQ WKQNKYYCDH QRGQKCVEFS SVDNIVQHSP QLSSPIISPA QSPAPAQLST
   901  LKTVRPSGPP LSIMPQFSRP FVPGQGDSRY PLLGQPLQYN PPAVLHGHIP NQQGQPGSRH
   961  GNRGRRQAKK AASTDLGAGE TVVGKVLEIT ELPDGITRME AEKLFGELFK IGAKIRWLRD
  1021  PQSQPRRHPL CCGSGDNTAN PERSKPSDLA STYTVLATFP SISAAQNALK KQINSVNKFK
  1081  LRTSKKHYDF HILERASSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against R3HDM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 63 nTPM
thymus: 41 nTPM
cerebellum: 28 nTPM
amygdala: 24 nTPM
bone marrow: 22 nTPM
parathyroid gland: 21 nTPM

Single-cell type

sertoli cells: 646 nCPM
brain excitatory neurons: 626 nCPM
thyrotrophs: 543 nCPM
brain inhibitory neurons: 533 nCPM
somatotrophs: 490 nCPM
lactotrophs: 482 nCPM

Immune cell

plasmacytoid DC: 11 nTPM
myeloid DC: 9.9 nTPM
NK-cell: 9.1 nTPM
T-reg: 8.6 nTPM
memory CD8 T-cell: 7.7 nTPM
intermediate monocyte: 7.4 nTPM

Brain region

cerebral cortex: 243 nTPM
basal ganglia: 125 nTPM
white matter: 123 nTPM
amygdala: 81 nTPM
hippocampal formation: 77 nTPM
thalamus: 69 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.86
gnomAD missense Z: 1.85
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of R3HDM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads R3HDM1 as an antibody target. Whether an autoantibody or antibody against R3HDM1 could matter depends on whether native R3HDM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

R3HDM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label R3HDM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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