Seroatlas · Human Serome Atlas

CD226

CD226 antigen

Also known as: CD226_HUMAN, DNAM-1, DNAM1, PTA1, TLiSA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15762
Gene
CD226
Ensembl
ENSG00000150637
Chromosome
18
Canonical length
336 aa
Protein class
CD markers, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Plasma membrane,Centriolar satellite

OverviewNCBI Gene

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>Q15762|CD226
     1  MDYPTLLLAL LHVYRALCEE VLWHTSVPFA ENMSLECVYP SMGILTQVEW FKIGTQQDSI
    61  AIFSPTHGMV IRKPYAERVY FLNSTMASNN MTLFFRNASE DDVGYYSCSL YTYPQGTWQK
   121  VIQVVQSDSF EAAVPSNSHI VSEPGKNVTL TCQPQMTWPV QAVRWEKIQP RQIDLLTYCN
   181  LVHGRNFTSK FPRQIVSNCS HGRWSVIVIP DVTVSDSGLY RCYLQASAGE NETFVMRLTV
   241  AEGKTDNQYT LFVAGGTVLL LLFVISITTI IVIFLNRRRR RERRDLFTES WDTQKAPNNY
   301  RSPISTSQPT NQSMDDTRED IYVNYPTFSR RPKTRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD226 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 59 nTPM
  • spleen: 19 nTPM
  • lymph node: 9 nTPM
  • tonsil: 6.7 nTPM
  • thymus: 6 nTPM
  • appendix: 5.4 nTPM

Single-cell type

  • platelets: 1,419 nCPM
  • megakaryocytes: 210 nCPM
  • nk-cells: 175 nCPM
  • t-cells: 174 nCPM
  • microglia: 100 nCPM
  • innate lymphoid cells: 73 nCPM

Immune cell

  • gdT-cell: 37 nTPM
  • NK-cell: 30 nTPM
  • memory CD4 T-cell: 29 nTPM
  • memory CD8 T-cell: 23 nTPM
  • naive CD8 T-cell: 17 nTPM
  • naive CD4 T-cell: 16 nTPM

Brain region

  • basal ganglia: 16 nTPM
  • thalamus: 14 nTPM
  • midbrain: 9.5 nTPM
  • medulla oblongata: 9.2 nTPM
  • white matter: 9.1 nTPM
  • pons: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0.04
gnomAD missense Z
0.74
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD226 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD226 as an antibody target. Whether an autoantibody or antibody against CD226 could matter depends on whether native CD226 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD226 is annotated at the cell surface, where native CD226 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD226 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD226. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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