Seroatlas · Human Serome Atlas

SFTPC

Surfactant protein C

Also known as: BRICD6, PSP-C, PSPC_HUMAN, SFTP2, SMDP2, SP-C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P11686
Gene
SFTPC
Ensembl
ENSG00000168484
Chromosome
8
Canonical length
197 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>P11686|SFTPC
     1  MDVGSKEVLM ESPPDYSAAP RGRFGIPCCP VHLKRLLIVV VVVVLIVVVI VGALLMGLHM
    61  SQKHTEMVLE MSIGAPEAQQ RLALSEHLVT TATFSIGSTG LVVYDYQQLL IAYKPAPGTC
   121  CYIMKIAPES IPSLEALTRK VHNFQMECSL QAKPAVPTSK LGQAEGRDAG SAPSGGDPAF
   181  LGMAVSTLCG EVPLYYI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFTPC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
17,411 nTPM

Expression across tissuesHPA

Tissue

  • lung: 17,411 nTPM
  • adrenal gland: 22 nTPM
  • ovary: 20 nTPM
  • spinal cord: 16 nTPM
  • spleen: 13 nTPM
  • basal ganglia: 12 nTPM

Single-cell type

  • alveolar cells type 2: 101,266 nCPM
  • transitional alveolar cells: 15,492 nCPM
  • alveolar cells type 1: 1,380 nCPM
  • respiratory ionocytes: 658 nCPM
  • submucosal glandular cells: 320 nCPM
  • respiratory ciliated cells: 231 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 14 nTPM
  • basal ganglia: 8.3 nTPM
  • medulla oblongata: 8 nTPM
  • cerebral cortex: 7.2 nTPM
  • thalamus: 6.8 nTPM
  • midbrain: 6.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SFTPC.

Disease | AllUniProt

Conditions SFTPC is implicated in, by any mechanism.

  • Pulmonary surfactant metabolism dysfunction 2 (SMDP2) MIM:610913

Disease | GeneticClinVar

29 pathogenic / likely-pathogenic of 206 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
0.85
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • BRICHOS domain
  • BRICHOS domain
  • Pulmonary surfactant-associated protein C
  • Surfactant protein C, N-terminal propeptide
  • Surfactant-associated polypeptide, palmitoylation site
  • Surfactant protein C, N terminal propeptide

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SFTPC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SFTPC as an antibody target. Whether an autoantibody or antibody against SFTPC could matter depends on whether native SFTPC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SFTPC is annotated as secreted, so native SFTPC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SFTPC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SFTPC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...