Seroatlas · Human Serome Atlas

CD96

T-cell surface protein tactile

Also known as: TACT_HUMAN, TACTILE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P40200
Gene: CD96
Ensembl: ENSG00000153283
Chromosome: 3
Canonical length: 585 aa
Protein class: CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>P40200|CD96
     1  MEKKWKYCAV YYIIQIHFVK GVWEKTVNTE ENVYATLGSD VNLTCQTQTV GFFVQMQWSK
    61  VTNKIDLIAV YHPQYGFYCA YGRPCESLVT FTETPENGSK WTLHLRNMSC SVSGRYECML
   121  VLYPEGIQTK IYNLLIQTHV TADEWNSNHT IEIEINQTLE IPCFQNSSSK ISSEFTYAWS
   181  VENSSTDSWV LLSKGIKEDN GTQETLISQN HLISNSTLLK DRVKLGTDYR LHLSPVQIFD
   241  DGRKFSCHIR VGPNKILRSS TTVKVFAKPE IPVIVENNST DVLVERRFTC LLKNVFPKAN
   301  ITWFIDGSFL HDEKEGIYIT NEERKGKDGF LELKSVLTRV HSNKPAQSDN LTIWCMALSP
   361  VPGNKVWNIS SEKITFLLGS EISSTDPPLS VTESTLDTQP SPASSVSPAR YPATSSVTLV
   421  DVSALRPNTT PQPSNSSMTT RGFNYPWTSS GTDTKKSVSR IPSETYSSSP SGAGSTLHDN
   481  VFTSTARAFS EVPTTANGST KTNHVHITGI VVNKPKDGMS WPVIVAALLF CCMILFGLGV
   541  RKWCQYQKEI MERPPPFKPP PPPIKYTCIQ EPNESDLPYH EMETL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD96 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

thymus: 58 nTPM
lymph node: 25 nTPM
tonsil: 19 nTPM
bone marrow: 15 nTPM
spleen: 12 nTPM
appendix: 12 nTPM

Single-cell type

t-cells: 830 nCPM
innate lymphoid cells: 735 nCPM
nk-cells: 657 nCPM
thymocytes: 583 nCPM
urothelial cells: 299 nCPM
adipocytes: 232 nCPM

Immune cell

MAIT T-cell: 117 nTPM
memory CD8 T-cell: 85 nTPM
naive CD8 T-cell: 82 nTPM
NK-cell: 80 nTPM
gdT-cell: 74 nTPM
naive CD4 T-cell: 69 nTPM

Brain region

white matter: 7.7 nTPM
choroid plexus: 7 nTPM
medulla oblongata: 6.9 nTPM
cerebral cortex: 6.1 nTPM
cerebellum: 5.5 nTPM
pons: 5.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CD96.

Disease | AllUniProt

Conditions CD96 is implicated in, by any mechanism.

C syndrome (CSYN) MIM:211750

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 203 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

C syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: -0.47
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD96 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD96 as an antibody target. Whether an autoantibody or antibody against CD96 could matter depends on whether native CD96 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD96 is annotated at the cell surface, where native CD96 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD96 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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