Seroatlas · Human Serome Atlas

FAM220A

Protein FAM220A

Also known as: ACPIN1, C7orf70, F220A_HUMAN, MGC12966, SIPAR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z4H9
Gene: FAM220A
Ensembl: ENSG00000178397
Chromosome: 7
Canonical length: 259 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable STAT family protein binding activity. Predicted to be involved in intracellular signal transduction and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in acrosomal vesicle. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q7Z4H9|FAM220A
     1  MRDRRGPLGT CLAQVQQAGG GDSDKLSCSL KKRMPEGPWP ADAPSWMNKP VVDGNSQSEA
    61  LSLEMRKDPS GAGLWLHSGG PVLPYVRESV RRNPASAATP STAVGLFPAP TECFARVSCS
   121  GVEALGRRDW LGGGPRATDG HRGQCPKGEP RVSRLPRHQK VPEMGSFQDD PPSAFPKGLG
   181  SELEPACLHS ILSATLHVYP EVLLSEETKR IFLDRLKPMF SKQTIEFKKM LKSTSDGLQI
   241  TLGLLALQPF ELANTLCHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM220A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

testis: 73 nTPM
skeletal muscle: 66 nTPM
cerebellum: 19 nTPM
cerebral cortex: 19 nTPM
tongue: 18 nTPM
heart muscle: 15 nTPM

Single-cell type

distal convoluted tubule cells: 5.5 nCPM
renal collecting duct intercalated cells: 5.1 nCPM
renal connecting tubule cells: 4.8 nCPM
loop of henle epithelial cells: 4.6 nCPM
podocytes: 3.9 nCPM
proximal tubule cells: 3.9 nCPM

Immune cell

NK-cell: 7.3 nTPM
memory B-cell: 5.8 nTPM
eosinophil: 4.9 nTPM
naive CD4 T-cell: 4.9 nTPM
naive B-cell: 4.8 nTPM
myeloid DC: 4.6 nTPM

Brain region

cerebellum: 16 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 12 nTPM
thalamus: 12 nTPM
hypothalamus: 11 nTPM
white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -1.35
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of transcription by RNA polymerase II

Molecular functions

STAT family protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM220A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PTPN2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM220A as an antibody target. Whether an autoantibody or antibody against FAM220A could matter depends on whether native FAM220A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM220A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM220A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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