Seroatlas · Human Serome Atlas

CNNM3

Metal transporter CNNM3

Also known as: ACDP3, CNNM3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NE01
Gene
CNNM3
Ensembl
ENSG00000168763
Chromosome
2
Canonical length
707 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in magnesium ion homeostasis. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

707 residues, UniProt reviewed canonical sequence.

>Q8NE01|CNNM3
     1  MAAAVAAAGR LGWLFAALCL GNAAGEAAPG PRVLGFCLEE DGAAGAGWVR GGAARDTPDA
    61  TFLLRLFGPG FANSSWSWVA PEGAGCREEA ASPAGEWRAL LRLRLRAEAV RPHSALLAVR
   121  VEPGGGAAEE AAPPWALGLG AAGLLALAAL ARGLQLSALA LAPAEVQVLR ESGSEAERAA
   181  ARRLEPARRW AGCALGALLL LASLAQAALA VLLYRAAGQR AVPAVLGSAG LVFLVGEVVP
   241  AAVSGRWTLA LAPRALGLSR LAVLLTLPVA LPVGQLLELA ARPGRLRERV LELARGGGDP
   301  YSDLSKGVLR CRTVEDVLTP LEDCFMLDAS TVLDFGVLAS IMQSGHTRIP VYEEERSNIV
   361  DMLYLKDLAF VDPEDCTPLS TITRFYNHPL HFVFNDTKLD AVLEEFKRGK SHLAIVQKVN
   421  NEGEGDPFYE VLGLVTLEDV IEEIIRSEIL DESEDYRDTV VKRKPASLMA PLKRKEEFSL
   481  FKVSDDEYKV TISPQLLLAT QRFLSREVDV FSPLRISEKV LLHLLKHPSV NQEVRFDESN
   541  RLATHHYLYQ RSQPVDYFIL ILQGRVEVEI GKEGLKFENG AFTYYGVSAL TVPSSVHQSP
   601  VSSLQPIRHD LQPDPGDGTH SSAYCPDYTV RALSDLQLIK VTRLQYLNAL LATRAQNLPQ
   661  SPENTDLQVI PGSQTRLLGE KTTTAAGSSH SRPGVPVEGS PGRNPGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNNM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 42 nTPM
  • pancreas: 25 nTPM
  • liver: 20 nTPM
  • parathyroid gland: 20 nTPM
  • cerebellum: 20 nTPM
  • duodenum: 16 nTPM

Single-cell type

  • hepatocytes: 49 nCPM
  • epicardial cells: 46 nCPM
  • cardiomyocytes: 45 nCPM
  • retinal horizontal cells: 42 nCPM
  • gastric chief cells: 36 nCPM
  • parietal cells: 35 nCPM

Immune cell

  • eosinophil: 3.5 nTPM
  • neutrophil: 3.3 nTPM
  • gdT-cell: 2.6 nTPM
  • T-reg: 2.2 nTPM
  • memory CD8 T-cell: 2.1 nTPM
  • naive B-cell: 2.1 nTPM

Brain region

  • cerebellum: 33 nTPM
  • white matter: 27 nTPM
  • basal ganglia: 23 nTPM
  • cerebral cortex: 22 nTPM
  • medulla oblongata: 21 nTPM
  • midbrain: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
gnomAD missense Z
0.76
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNNM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNNM3 as an antibody target. Whether an autoantibody or antibody against CNNM3 could matter depends on whether native CNNM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNNM3 is annotated at the cell surface, where native CNNM3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CNNM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CNNM3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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