Seroatlas · Human Serome Atlas

CNNM1

Metal transporter CNNM1

Also known as: ACDP1, CNNM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRU3
Gene
CNNM1
Ensembl
ENSG00000119946
Chromosome
10
Canonical length
951 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the ancient conserved domain protein family. The encoded protein may bind copper. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

951 residues, UniProt reviewed canonical sequence.

>Q9NRU3|CNNM1
     1  MAAAAAAAAA VGVRLRDCCS RGAVLLLFFS LSPRPPAAAA WLLGLRPEDT AGGRVSLEGG
    61  TLRAAEGTSF LLRVYFQPGP PATAAPVPSP TLNSGENGTG DWAPRLVFIE EPPGGGGVAP
   121  SAVPTRPPGP QRCREQSDWA SDVEVLGPLR PGGVAGSALV QVRVRELRKG EAERGGAGGG
   181  GKLFSLCAWD GRAWHHHGAA GGFLLRVRPR LYGPGGDLLP PAWLRALGAL LLLALSALFS
   241  GLRLSLLSLD PVELRVLRNS GSAAEQEQAR RVQAVRGRGT HLLCTLLLGQ AGANAALAGW
   301  LYTSLPPGFG GTGEDYSEEG IHFPWLPALV CTGAVFLGAE ICPYSVCSRH GLAIASHSVC
   361  LTRLLMAAAF PVCYPLGRLL DWALRQEIST FYTREKLLET LRAADPYSDL VKEELNIIQG
   421  ALELRTKVVE EVLTPLGDCF MLRSDAVLDF ATVSEILRSG YTRIPVYEGD QRHNIVDILF
   481  VKDLAFVDPD DCTPLLTVTR FYNRPLHCVF NDTRLDTVLE EFKKGKSHLA IVQRVNNEGE
   541  GDPFYEVMGI VTLEDIIEEI IKSEILDETD LYTDNRKKQR VPQRERKRHD FSLFKLSDTE
   601  MRVKISPQLL LATHRFMATE VEPFKSLYLS EKILLRLLKH PNVIQELKFD EKNKKAPEHY
   661  LYQRNRPVDY FVLLLQGKVE VEVGKEGLRF ENGAFTYYGV PAIMTTACSD NDVRKVGSLA
   721  GSSVFLNRSP SRCSGLNRSE SPNRERSDFG GSNTQLYSSS NNLYMPDYSV HILSDVQFVK
   781  ITRQQYQNAL TACHMDSSPQ SPDMEAFTDG DSTKAPTTRG TPQTPKDDPA ITLLNNRNSL
   841  PCSRSDGLRS PSEVVYLRME ELAFTQEEMT DFEEHSTQQL TLSPAAVPTR AASDSECCNI
   901  NLDTETSPCS SDFEENVGKK LLRTLSGQKR KRSPEGERTS EDNSNLTPLI T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNNM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 13 nTPM
  • cerebral cortex: 12 nTPM
  • cerebellum: 12 nTPM
  • testis: 9.8 nTPM
  • hypothalamus: 6.9 nTPM
  • hippocampal formation: 5.5 nTPM

Single-cell type

  • early spermatids: 182 nCPM
  • sertoli cells: 160 nCPM
  • late spermatids: 152 nCPM
  • brain inhibitory neurons: 98 nCPM
  • retinal horizontal cells: 84 nCPM
  • thyrotrophs: 65 nCPM

Immune cell

  • naive CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 45 nTPM
  • white matter: 30 nTPM
  • basal ganglia: 30 nTPM
  • hypothalamus: 24 nTPM
  • cerebellum: 20 nTPM
  • thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.02
gnomAD missense Z
2.74
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNNM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNNM1 as an antibody target. Whether an autoantibody or antibody against CNNM1 could matter depends on whether native CNNM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNNM1 is annotated at the cell surface, where native CNNM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CNNM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CNNM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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