Seroatlas · Human Serome Atlas

FNTA

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Also known as: FNTA_HUMAN, FPTA, PGGT1A, PTAR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49354
Gene: FNTA
Ensembl: ENSG00000168522
Chromosome: 8
Canonical length: 379 aa
Protein class: Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

379 residues, UniProt reviewed canonical sequence.

>P49354|FNTA
     1  MAATEGVGEA AQGGEPGQPA QPPPQPHPPP PQQQHKEEMA AEAGEAVASP MDDGFVSLDS
    61  PSYVLYRDRA EWADIDPVPQ NDGPNPVVQI IYSDKFRDVY DYFRAVLQRD ERSERAFKLT
   121  RDAIELNAAN YTVWHFRRVL LKSLQKDLHE EMNYITAIIE EQPKNYQVWH HRRVLVEWLR
   181  DPSQELEFIA DILNQDAKNY HAWQHRQWVI QEFKLWDNEL QYVDQLLKED VRNNSVWNQR
   241  YFVISNTTGY NDRAVLEREV QYTLEMIKLV PHNESAWNYL KGILQDRGLS KYPNLLNQLL
   301  DLQPSHSSPY LIAFLVDIYE DMLENQCDNK EDILNKALEL CEILAKEKDT IRKEYWRYIG
   361  RSLQSKHSTE NDSPTNVQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FNTA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 175 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 175 nTPM
midbrain: 83 nTPM
skeletal muscle: 79 nTPM
tongue: 60 nTPM
adipose tissue: 58 nTPM
hippocampal formation: 55 nTPM

Single-cell type

syncytiotrophoblasts: 251 nCPM
esophageal suprabasal cells: 179 nCPM
esophageal apical cells: 164 nCPM
migrating cytotrophoblasts: 159 nCPM
extravillous trophoblasts: 154 nCPM
cytotrophoblasts: 150 nCPM

Immune cell

NK-cell: 16 nTPM
naive B-cell: 15 nTPM
eosinophil: 14 nTPM
T-reg: 14 nTPM
memory B-cell: 14 nTPM
myeloid DC: 13 nTPM

Brain region

white matter: 88 nTPM
medulla oblongata: 67 nTPM
cerebellum: 62 nTPM
spinal cord: 61 nTPM
basal ganglia: 51 nTPM
pons: 47 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FNTA.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 64 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hypercholesterolemia, familial, 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.95
gnomAD missense Z: 0.8
DepMap mean gene effect: -1.05
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FNTA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FNTA as an antibody target. Whether an autoantibody or antibody against FNTA could matter depends on whether native FNTA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FNTA is annotated at the cell surface, where native FNTA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FNTA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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