MT-ATP8
ATP synthase F(0) complex subunit 8
Also known as: A6L, ATP8, ATP8_HUMAN, MTATP8, URFA6L
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P03928
- Gene
- MT-ATP8
- Ensembl
- ENSG00000228253
- Chromosome
- MT
- Canonical length
- 68 aa
- Protein class
- Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
- Quaternary structure
- Homooctamer
OverviewNCBI Gene
Contributes to proton-transporting ATP synthase activity, rotational mechanism. Involved in proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrion. Part of proton-transporting ATP synthase complex. Implicated in multiple sclerosis and urinary bladder cancer. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
68 residues, UniProt reviewed canonical sequence.
>P03928|MT-ATP8
1 MPQLNTTVWP TMITPMLLTL FLITQLKMLN TNYHLPPSPK PMKMKNYNKP WEPKWTKICS
61 LHSLPPQSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MT-ATP8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 355,486 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 355,486 nTPM
- skeletal muscle: 180,164 nTPM
- basal ganglia: 156,047 nTPM
- liver: 150,369 nTPM
- hippocampal formation: 138,294 nTPM
- amygdala: 132,058 nTPM
Single-cell type
- hepatocytes: 411 nCPM
- platelets: 317 nCPM
- urothelial cells: 311 nCPM
- pancreatic acinar cells: 304 nCPM
- prostatic hillock cells: 274 nCPM
- prostatic glandular cells: 263 nCPM
Immune cell
- basophil: 10,767 nTPM
- eosinophil: 2,201 nTPM
- classical monocyte: 1,806 nTPM
- memory B-cell: 1,780 nTPM
- naive B-cell: 1,625 nTPM
- naive CD8 T-cell: 1,624 nTPM
Brain region
- choroid plexus: 104,631 nTPM
- cerebral cortex: 91,300 nTPM
- pons: 84,956 nTPM
- midbrain: 84,439 nTPM
- medulla oblongata: 69,614 nTPM
- thalamus: 53,477 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about MT-ATP8.
Disease | AllUniProt
Conditions MT-ATP8 is implicated in, by any mechanism.
- Mitochondrial complex V deficiency, mitochondrial 2 (MC5DM2) MIM:516070
- Cardiomyopathy, infantile hypertrophic (CMHI) MIM:500006
Disease | GeneticClinVar
4 pathogenic / likely-pathogenic of 72 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- ATP synthase protein 8, metazoa
- ATP synthase protein 8, mammals
- ATP synthase protein 8
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MT-ATP8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MT-ATP8 as an antibody target. Whether an autoantibody or antibody against MT-ATP8 could matter depends on whether native MT-ATP8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MT-ATP8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MT-ATP8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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