Seroatlas · Human Serome Atlas

PLEKHA5

Pleckstrin homology domain-containing family A member 5

Also known as: FLJ10667, KIAA1686, PEPP2, PKHA5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HAU0
Gene: PLEKHA5
Ensembl: ENSG00000052126
Chromosome: 12
Canonical length: 1116 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to act upstream of or within reproductive system development. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1116 residues, UniProt reviewed canonical sequence.

>Q9HAU0|PLEKHA5
     1  MAADLNLEWI SLPRSWTYGI TRGGRVFFIN EEAKSTTWLH PVTGEAVVTG HRRQSTDLPT
    61  GWEEAYTFEG ARYYINHNER KVTCKHPVTG QPSQDNCIFV VNEQTVATMT SEEKKERPIS
   121  MINEASNYNV TSDYAVHPMS PVGRTSRASK KVHNFGKRSN SIKRNPNAPV VRRGWLYKQD
   181  STGMKLWKKR WFVLSDLCLF YYRDEKEEGI LGSILLPSFQ IALLTSEDHI NRKYAFKAAH
   241  PNMRTYYFCT DTGKEMELWM KAMLDAALVQ TEPVKRVDKI TSENAPTKET NNIPNHRVLI
   301  KPEIQNNQKN KEMSKIEEKK ALEAEKYGFQ KDGQDRPLTK INSVKLNSLP SEYESGSACP
   361  AQTVHYRPIN LSSSENKIVN VSLADLRGGN RPNTGPLYTE ADRVIQRTNS MQQLEQWIKI
   421  QKGRGHEEET RGVISYQTLP RNMPSHRAQI MARYPEGYRT LPRNSKTRPE SICSVTPSTH
   481  DKTLGPGAEE KRRSMRDDTM WQLYEWQQRQ FYNKQSTLPR HSTLSSPKTM VNISDQTMHS
   541  IPTSPSHGSI AAYQGYSPQR TYRSEVSSPI QRGDVTIDRR HRAHHPKHVY VPDRRSVPAG
   601  LTLQSVSPQS LQGKTLSQDE GRGTLYKYRP EEVDIDAKLS RLCEQDKVVH ALEEKLQQLH
   661  KEKYTLEQAL LSASQEIEMH ADNPAAIQTV VLQRDDLQNG LLSTCRELSR ATAELERAWR
   721  EYDKLEYDVT VTRNQMQEQL DHLGEVQTES AGIQRAQIQK ELWRIQDVME GLSKHKQQRG
   781  TTEIGMIGSK PFSTVKYKNE GPDYRLYKSE PELTTVAEVD ESNGEEKSEP VSEIETSVVK
   841  GSHFPVGVVP PRAKSPTPES STIASYVTLR KTKKMMDLRT ERPRSAVEQL CLAESTRPRM
   901  TVEEQMERIR RHQQACLREK KKGLNVIGAS DQSPLQSPSN LRDNPFRTTQ TRRRDDKELD
   961  TAIRENDVKP DHETPATEIV QLKETEPQNV DFSKELKKTE NISYEMLFEP EPNGVNSVEM
  1021  MDKERNKDKM PEDVTFSPQD ETQTANHKPE EHPEENTKNS VDEQEETVIS YESTPEVSRG
  1081  NQTMAVKSLS PSPESSASPV PSTQPQLTEG SHFMCV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 58 nTPM
kidney: 38 nTPM
heart muscle: 30 nTPM
cervix: 28 nTPM
epididymis: 26 nTPM
endometrium: 25 nTPM

Single-cell type

ependymal cells: 2,160 nCPM
melanocytes: 1,781 nCPM
pituicytes/fscs: 1,478 nCPM
cardiomyocytes: 1,281 nCPM
proximal tubule cells: 1,256 nCPM
respiratory basal cells: 1,188 nCPM

Immune cell

basophil: 11 nTPM
MAIT T-cell: 2.2 nTPM
T-reg: 1.4 nTPM
gdT-cell: 1.1 nTPM
memory CD4 T-cell: 1.1 nTPM
plasmacytoid DC: 1.1 nTPM

Brain region

cerebral cortex: 50 nTPM
medulla oblongata: 48 nTPM
basal ganglia: 47 nTPM
midbrain: 46 nTPM
white matter: 43 nTPM
spinal cord: 41 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLEKHA5.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 193 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.1
gnomAD pLI: 1
gnomAD missense Z: 1.24
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

reproductive system development

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLEKHA5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHA5 as an antibody target. Whether an autoantibody or antibody against PLEKHA5 could matter depends on whether native PLEKHA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLEKHA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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