Seroatlas · Human Serome Atlas

PDZD11

PDZ domain-containing protein 11

Also known as: PDZ11_HUMAN, PDZK11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5EBL8
Gene: PDZD11
Ensembl: ENSG00000120509
Chromosome: X
Canonical length: 140 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable protein-macromolecule adaptor activity. Involved in pore complex assembly. Located in basolateral plasma membrane and cytosol. Part of pore complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>Q5EBL8|PDZD11
     1  MDSRIPYDDY PVVFLPAYEN PPAWIPPHER VHHPDYNNEL TQFLPRTITL KKPPGAQLGF
    61  NIRGGKASQL GIFISKVIPD SDAHRAGLQE GDQVLAVNDV DFQDIEHSKA VEILKTAREI
   121  SMRVRFFPYN YHRQKERTVH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDZD11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

midbrain: 70 nTPM
cerebral cortex: 69 nTPM
hypothalamus: 68 nTPM
amygdala: 67 nTPM
choroid plexus: 63 nTPM
hippocampal formation: 58 nTPM

Single-cell type

esophageal apical cells: 186 nCPM
esophageal suprabasal cells: 141 nCPM
decidual stromal cells: 105 nCPM
esophageal basal cells: 98 nCPM
hofbauer cells: 82 nCPM
extravillous trophoblasts: 77 nCPM

Immune cell

T-reg: 78 nTPM
non-classical monocyte: 63 nTPM
intermediate monocyte: 48 nTPM
memory CD8 T-cell: 46 nTPM
MAIT T-cell: 45 nTPM
memory CD4 T-cell: 41 nTPM

Brain region

pons: 40 nTPM
hypothalamus: 38 nTPM
white matter: 36 nTPM
thalamus: 33 nTPM
midbrain: 33 nTPM
medulla oblongata: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0.2
gnomAD missense Z: 1.75
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-macromolecule adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDZD11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDZD11 as an antibody target. Whether an autoantibody or antibody against PDZD11 could matter depends on whether native PDZD11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDZD11 is annotated at the cell surface, where native PDZD11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PDZD11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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