Seroatlas · Human Serome Atlas

PLAUR

Urokinase plasminogen activator surface receptor

Also known as: CD87, UPAR, UPAR_HUMAN, URKR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q03405
Gene
PLAUR
Ensembl
ENSG00000011422
Chromosome
19
Canonical length
335 aa
Protein class
Cancer-related genes, CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q03405|PLAUR
     1  MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI VRLWEEGEEL
    61  ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ GNSGRAVTYS RSRYLECISC
   121  GSSDMSCERG RHQSLQCRSP EEQCLDVVTH WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG
   181  FHNNDTFHFL KCCNTTKCNE GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP
   241  MNQCLVATGT HEPKNQSYMV RGCATASMCQ HAHLGDAFSM NHIDVSCCTK SGCNHPDLDV
   301  QYRSGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLAUR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
651 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 651 nTPM
  • urinary bladder: 102 nTPM
  • appendix: 78 nTPM
  • lung: 76 nTPM
  • gallbladder: 73 nTPM
  • adipose tissue: 53 nTPM

Single-cell type

  • neutrophils: 7,138 nCPM
  • epididymal basal cells: 3,927 nCPM
  • monocytes: 2,786 nCPM
  • ocular epithelial cells: 2,333 nCPM
  • cdc: 1,115 nCPM
  • endometrial secretory cells: 875 nCPM

Immune cell

  • neutrophil: 1,177 nTPM
  • eosinophil: 748 nTPM
  • non-classical monocyte: 554 nTPM
  • classical monocyte: 478 nTPM
  • intermediate monocyte: 428 nTPM
  • total PBMC: 254 nTPM

Brain region

  • cerebral cortex: 71 nTPM
  • thalamus: 55 nTPM
  • white matter: 30 nTPM
  • pons: 29 nTPM
  • medulla oblongata: 27 nTPM
  • cerebellum: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0.01
gnomAD missense Z
0.41
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLAUR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLAUR as an antibody target. Whether an autoantibody or antibody against PLAUR could matter depends on whether native PLAUR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLAUR is annotated at the cell surface, where native PLAUR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLAUR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLAUR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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