PLGRKT
Plasminogen receptor (KT)
Also known as: AD025, C9orf46, FLJ14688, MDS030, Plg-RKT, PLRKT_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9HBL7
- Gene
- PLGRKT
- Ensembl
- ENSG00000107020
- Chromosome
- 9
- Canonical length
- 147 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
Predicted to be involved in positive regulation of plasminogen activation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
147 residues, UniProt reviewed canonical sequence.
>Q9HBL7|PLGRKT
1 MGFIFSKSMN ESMKNQKEFM LMNARLQLER QLIMQSEMRE RQMAMQIAWS REFLKYFGTF
61 FGLAAISLTA GAIKKKKPAF LVPIVPLSFI LTYQYDLGYG TLLERMKGEA EDILETEKSK
121 LQLPRGMITF ESIEKARKEQ SRFFIDKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PLGRKT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 55 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 55 nTPM
- rectum: 44 nTPM
- duodenum: 42 nTPM
- colon: 39 nTPM
- choroid plexus: 35 nTPM
- tongue: 35 nTPM
Single-cell type
- enterocytes: 178 nCPM
- colonocytes: 164 nCPM
- extravillous trophoblasts: 146 nCPM
- enteric transient amplifying cells: 132 nCPM
- gastric progenitor cells: 129 nCPM
- mast cells: 125 nCPM
Immune cell
- basophil: 246 nTPM
- T-reg: 75 nTPM
- memory CD8 T-cell: 57 nTPM
- MAIT T-cell: 54 nTPM
- memory CD4 T-cell: 54 nTPM
- NK-cell: 53 nTPM
Brain region
- choroid plexus: 20 nTPM
- white matter: 10 nTPM
- medulla oblongata: 9.8 nTPM
- spinal cord: 9.7 nTPM
- basal ganglia: 9.1 nTPM
- cerebellum: 9.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.87
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.09
- DepMap mean gene effect
- 0.28
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Plasminogen receptor (KT)
- Uncharacterised conserved protein (DUF2368)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PLGRKT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PLGRKT as an antibody target. Whether an autoantibody or antibody against PLGRKT could matter depends on whether native PLGRKT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PLGRKT is annotated at the cell surface, where native PLGRKT is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label PLGRKT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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