Seroatlas · Human Serome Atlas

PLA2G1B

Phospholipase A2

Also known as: PA21B_HUMAN, PLA2, PLA2A, PPLA2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P04054
Gene
PLA2G1B
Ensembl
ENSG00000170890
Chromosome
12
Canonical length
148 aa
Protein class
Candidate cardiovascular disease genes, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins
Secretome location
Secreted to digestive system
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>P04054|PLA2G1B
     1  MKLLVLAVLL TVAAADSGIS PRAVWQFRKM IKCVIPGSDP FLEYNNYGCY CGLGGSGTPV
    61  DELDKCCQTH DNCYDQAKKL DSCKFLLDNP YTHTYSYSCS GSAITCSSKN KECEAFICNC
   121  DRNAAICFSK APYNKAHKNL DTKKYCQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLA2G1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
110,914 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 110,914 nTPM
  • ovary: 38 nTPM
  • lung: 30 nTPM
  • heart muscle: 20 nTPM
  • salivary gland: 20 nTPM
  • duodenum: 15 nTPM

Single-cell type

  • pancreatic acinar cells: 42,773 nCPM
  • alveolar cells type 2: 330 nCPM
  • pancreatic duct cells: 169 nCPM
  • late spermatids: 73 nCPM
  • parietal cells: 42 nCPM
  • monocytes: 26 nCPM

Immune cell

  • naive CD4 T-cell: 0.5 nTPM
  • MAIT T-cell: 0.3 nTPM
  • NK-cell: 0.3 nTPM
  • gdT-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • total PBMC: 0.1 nTPM

Brain region

  • basal ganglia: 0.5 nTPM
  • cerebral cortex: 0.5 nTPM
  • hypothalamus: 0.5 nTPM
  • cerebellum: 0.4 nTPM
  • pons: 0.4 nTPM
  • amygdala: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.97
gnomAD pLI
0
gnomAD missense Z
-0.71
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLA2G1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLA2G1B as an antibody target. Whether an autoantibody or antibody against PLA2G1B could matter depends on whether native PLA2G1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLA2G1B is annotated as secreted, so native PLA2G1B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PLA2G1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLA2G1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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