PLA2G10
Group 10 secretory phospholipase A2
Also known as: GXPLA2, PA2GX_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O15496
- Gene
- PLA2G10
- Ensembl
- ENSG00000069764
- Chromosome
- 16
- Canonical length
- 165 aa
- Protein class
- Enzymes, FDA approved drug targets, Metabolic proteins, Predicted secreted proteins, RAS pathway related proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]
Canonical amino-acid sequenceUniProt
165 residues, UniProt reviewed canonical sequence.
>O15496|PLA2G10
1 MGPLPVCLPI MLLLLLPSLL LLLLLPGPGS GEASRILRVH RRGILELAGT VGCVGPRTPI
61 AYMKYGCFCG LGGHGQPRDA IDWCCHGHDC CYTRAEEAGC SPKTERYSWQ CVNQSVLCGP
121 AENKCQELLC KCDQEIANCL AQTEYNLKYL FYPQFLCEPD SPKCDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PLA2G10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 40 nTPM
Expression across tissuesHPA
Tissue
- stomach: 40 nTPM
- colon: 25 nTPM
- rectum: 22 nTPM
- pancreas: 9.7 nTPM
- small intestine: 8 nTPM
- duodenum: 7.2 nTPM
Single-cell type
- colonocytes: 151 nCPM
- goblet cells: 112 nCPM
- foveolar cells: 90 nCPM
- extravillous trophoblasts: 68 nCPM
- gastric progenitor cells: 62 nCPM
- endometrial luminal cells: 45 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.93
- gnomAD pLI
- 0.07
- gnomAD missense Z
- -0.03
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- arachidonate metabolic process
- arachidonate secretion
- axon guidance
- cellular response to leukemia inhibitory factor
- cholesterol homeostasis
- defense response to virus
- erythrocyte maturation
- fertilization
- hair follicle morphogenesis
- intestinal stem cell homeostasis
- low-density lipoprotein particle remodeling
- lysophospholipid transport
- macrophage activation
- negative regulation of cholesterol efflux
- negative regulation of cytokine production involved in inflammatory response
- negative regulation of inflammatory response
- negative regulation of transcription by RNA polymerase II
- phosphatidic acid metabolic process
- phosphatidylcholine catabolic process
- phosphatidylcholine metabolic process
- phosphatidylethanolamine metabolic process
- phosphatidylglycerol metabolic process
- phosphatidylserine metabolic process
- platelet activating factor catabolic process
- positive regulation of acrosome reaction
- positive regulation of arachidonate secretion
- positive regulation of lipid storage
- positive regulation of macrophage derived foam cell differentiation
- positive regulation of prostaglandin secretion
- positive regulation of protein metabolic process
- production of molecular mediator involved in inflammatory response
- prostaglandin biosynthetic process
- regulation of macrophage activation
- signal transduction involved in regulation of gene expression
- nuclear receptor-mediated signaling pathway
Molecular functions
- 1-alkyl-2-acetylglycerophosphocholine esterase activity
- calcium ion binding
- calcium-dependent phospholipase A2 activity
- phospholipase A2 activity
- phospholipase activity
- phospholipid binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PLA2G10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PLA2G10 as an antibody target. Whether an autoantibody or antibody against PLA2G10 could matter depends on whether native PLA2G10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PLA2G10 is annotated as secreted, so native PLA2G10 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label PLA2G10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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