PAZ domain superfamily

Definition

This domain superfamily is named after the proteins Piwi Argonaut and Zwille. It is also found in the CAF protein from Arabidopsis thaliana. The function of the domain is unknown but has been found in the middle region of a number of members of the Argonaute protein family, which also contain the Piwi domain ([interpro:IPR003165]) in their C-terminal region PMID:12906857. Several members of this family have been implicated in the development and maintenance of stem cells through the RNA-mediated gene-quelling mechanisms associated with the protein DICER.

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• AGO1
• AGO2
• AGO3
• AGO4
• DICER1
• PIWIL1
• PIWIL2
• PIWIL3
• PIWIL4