Seroatlas · Human Serome Atlas

TPD52

Tumor protein D52

Also known as: D52, hD52, N8L, TPD52_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P55327
Gene: TPD52
Ensembl: ENSG00000076554
Chromosome: 8
Canonical length: 224 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Primary cilium,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This locus represents naturally occurring readthrough transcription between the neighboring TPD52 (tumor protein D52) and MRPS28 (mitochondrial ribosomal protein S28) genes on chromosome 8. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2022]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>P55327|TPD52
     1  MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR TDPVPEEGED
    61  VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK EKHLAEIKRK LGINSLQELK
   121  QNIAKGWQDV TATSAYKKTS ETLSQAGQKA SAAFSSVGSV ITKKLEDVKN SPTFKSFEEK
   181  VENLKSKVGG TKPAGGDFGE VLNSAANASA TTTEPLPEKT QESL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPD52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 173 nTPM

Expression across tissuesHPA

Tissue

retina: 173 nTPM
rectum: 122 nTPM
colon: 110 nTPM
prostate: 98 nTPM
small intestine: 93 nTPM
duodenum: 92 nTPM

Single-cell type

plasma cells: 386 nCPM
choroid plexus epithelial cells: 361 nCPM
salivary ionocytes: 332 nCPM
b-cells: 328 nCPM
gonadotrophs: 239 nCPM
corticotrophs: 239 nCPM

Immune cell

memory B-cell: 50 nTPM
naive B-cell: 44 nTPM
MAIT T-cell: 22 nTPM
NK-cell: 15 nTPM
gdT-cell: 12 nTPM
memory CD4 T-cell: 12 nTPM

Brain region

thalamus: 92 nTPM
white matter: 80 nTPM
cerebral cortex: 78 nTPM
hippocampal formation: 69 nTPM
basal ganglia: 61 nTPM
midbrain: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: 0.9
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TPD52 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPD52 as an antibody target. Whether an autoantibody or antibody against TPD52 could matter depends on whether native TPD52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPD52 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPD52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...