Seroatlas · Human Serome Atlas

AIDA

Axin interactor, dorsalization-associated protein

Also known as: AIDA_HUMAN, C1orf80, FLJ12806

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96BJ3
Gene
AIDA
Ensembl
ENSG00000186063
Chromosome
1
Canonical length
306 aa
Protein class
Predicted intracellular proteins
Subcellular location
Microtubules,Cytokinetic bridge,Primary cilium,Basal body

OverviewNCBI Gene

Predicted to enable phosphatidylinositol binding activity. Acts upstream of or within negative regulation of JUN kinase activity. Predicted to be located in cytoplasm. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

306 residues, UniProt reviewed canonical sequence.

>Q96BJ3|AIDA
     1  MSEVTRSLLQ RWGASFRRGA DFDSWGQLVE AIDEYQILAR HLQKEAQAQH NNSEFTEEQK
    61  KTIGKIATCL ELRSAALQST QSQEEFKLED LKKLEPILKN ILTYNKEFPF DVQPVPLRRI
   121  LAPGEEENLE FEEDEEEGGA GAGSPDSFPA RVPGTLLPRL PSEPGMTLLT IRIEKIGLKD
   181  AGQCIDPYIT VSVKDLNGID LTPVQDTPVA SRKEDTYVHF NVDIELQKHV EKLTKGAAIF
   241  FEFKHYKPKK RFTSTKCFAF MEMDEIKPGP IVIELYKKPT DFKRKKLQLL TKKPLYLHLH
   301  QTLHKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AIDA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
68 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 68 nTPM
  • epididymis: 53 nTPM
  • smooth muscle: 51 nTPM
  • blood vessel: 50 nTPM
  • tonsil: 50 nTPM
  • lymph node: 48 nTPM

Single-cell type

  • microglia: 68 nCPM
  • b-cells: 50 nCPM
  • sertoli cells: 45 nCPM
  • erythrocyte progenitors: 37 nCPM
  • adipocytes: 33 nCPM
  • alveolar cells type 2: 32 nCPM

Immune cell

  • memory B-cell: 14 nTPM
  • naive B-cell: 14 nTPM
  • T-reg: 10 nTPM
  • naive CD4 T-cell: 7.4 nTPM
  • memory CD4 T-cell: 7.2 nTPM
  • plasmacytoid DC: 7.2 nTPM

Brain region

  • white matter: 75 nTPM
  • medulla oblongata: 65 nTPM
  • basal ganglia: 63 nTPM
  • hypothalamus: 62 nTPM
  • pons: 61 nTPM
  • spinal cord: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
0.96
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • C2 domain superfamily
  • Axin interactor, dorsalization-associated protein, N-terminal
  • Axin interactor dorsalization-associated protein, C-terminal
  • Axin interactor, dorsalization-associated protein, N-terminal domain superfamily
  • Aida N-terminus
  • Axin interactor dorsalisation-associated protein, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AIDA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AIDA as an antibody target. Whether an autoantibody or antibody against AIDA could matter depends on whether native AIDA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AIDA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AIDA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AIDA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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