BDKRB2

Protein identityUniProt · HPA

UniProt accession

P30411

Gene

BDKRB2

Ensembl

ENSG00000168398

Chromosome

14

Canonical length

391 aa

Protein class

FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters

Subcellular location

Vesicles,Plasma membrane,Cytokinetic bridge

OverviewNCBI Gene

This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020]

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>P30411|BDKRB2
     1  MFSPWKISMF LSVREDSVPT TASFSADMLN VTLQGPTLNG TFAQSKCPQV EWLGWLNTIQ
    61  PPFLWVLFVL ATLENIFVLS VFCLHKSSCT VAEIYLGNLA AADLILACGL PFWAITISNN
   121  FDWLFGETLC RVVNAIISMN LYSSICFLML VSIDRYLALV KTMSMGRMRG VRWAKLYSLV
   181  IWGCTLLLSS PMLVFRTMKE YSDEGHNVTA CVISYPSLIW EVFTNMLLNV VGFLLPLSVI
   241  TFCTMQIMQV LRNNEMQKFK EIQTERRATV LVLVVLLLFI ICWLPFQIST FLDTLHRLGI
   301  LSSCQDERII DVITQIASFM AYSNSCLNPL VYVIVGKRFR KKSWEVYQGV CQKGGCRSEP
   361  IQMENSMGTL RTSISVERQI HKLQDWAGSR Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BDKRB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

38 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.82

gnomAD pLI

0.12

gnomAD missense Z

0.98

DepMap mean gene effect

0.14

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• arachidonate secretion
• blood circulation
• cell surface receptor protein tyrosine kinase signaling pathway
• cell surface receptor signaling pathway
• G protein-coupled receptor signaling pathway
• inflammatory response
• positive regulation of cytosolic calcium ion concentration
• regulation of vascular permeability
• regulation of vasoconstriction
• response to salt stress
• smooth muscle contraction
• vasoconstriction
• vasodilation
• intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
• negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator

Molecular functions

• bradykinin receptor activity
• phosphatidylinositol-4,5-bisphosphate phospholipase C activity
• protease binding
• protein heterodimerization activity
• type 1 angiotensin receptor binding

Cellular components

• endosome
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• Bradykinin receptor family
• GPCR, rhodopsin-like, 7TM
• C-C chemokine receptor type 1-9-like
• 7 transmembrane receptor (rhodopsin family)
• Bradykinin receptor B2

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Lipoprotein
• Membrane
• Palmitate
• Phosphoprotein
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of BDKRB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PECAM1