CD177

Protein identityUniProt · HPA

UniProt accession

Q8N6Q3

Gene

CD177

Canonical length

437 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CD177 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>Q8N6Q3|CD177
     1  MSAVLLLALL GFILPLPGVQ ALLCQFGTVQ HVWKVSDLPR QWTPKNTSCD SGLGCQDTLM
    61  LIESGPQVSL VLSKGCTEAK DQEPRVTEHR MGPGLSLISY TFVCRQEDFC NNLVNSLPLW
   121  APQPPADPGS LRCPVCLSME GCLEGTTEEI CPKGTTHCYD GLLRLRGGGI FSNLRVQGCM
   181  PQPGCNLLNG TQEIGPVGMT ENCNRKDFLT CHRGTTIMTH GNLAQEPTDW TTSNTEMCEV
   241  GQVCQETLLL LDVGLTSTLV GTKGCSTVGA QNSQKTTIHS APPGVLVASY THFCSSDLCN
   301  SASSSSVLLN SLPPQAAPVP GDRQCPTCVQ PLGTCSSGSP RMTCPRGATH CYDGYIHLSG
   361  GGLSTKMSIQ GCVAQPSSFL LNHTRQIGIF SAREKRDVQP PASQHEGGGA EGLESLTWGV
   421  GLALAPALWW GVVCPSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD177 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

270 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for CD177 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect

-0.22

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell adhesion
• cell-cell adhesion via plasma-membrane adhesion molecules
• cell-cell junction maintenance
• innate immune response
• leukocyte cell-cell adhesion
• neutrophil extravasation
• neutrophil migration
• positive regulation of neutrophil degranulation
• positive regulation of superoxide anion generation
• protein localization to cell surface
• regulation of endocytosis
• regulation of integrin-mediated signaling pathway

Molecular functions

• calcium-dependent protein binding
• integrin binding
• protease binding

Cellular components

• extracellular exosome
• lamellipodium
• plasma membrane
• plasma membrane raft
• secretory granule membrane
• side of membrane
• specific granule membrane
• tertiary granule membrane

Protein domainsUniProt · Pfam · InterPro

• Ly-6 antigen/uPA receptor-like
• Snake toxin-like superfamily
• Fertilization and immune response mediator protein
• u-PAR/Ly-6 domain

KeywordsUniProt

• Cell adhesion
• Cell membrane
• Cell projection
• Glycoprotein
• GPI-anchor
• Immunity
• Innate immunity
• Lipoprotein
• Membrane
• Repeat
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of CD177 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PECAM1
• PRTN3