Seroatlas · Human Serome Atlas

PDE3B

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

Also known as: HcGIP1, PDE3B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13370
Gene
PDE3B
Ensembl
ENSG00000152270
Chromosome
11
Canonical length
1112 aa
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of lipid catabolic process; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in membrane. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1112 residues, UniProt reviewed canonical sequence.

>Q13370|PDE3B
     1  MRRDERDAKA MRSLQPPDGA GSPPESLRNG YVKSCVSPLR QDPPRGFFFH LCRFCNVELR
    61  PPPASPQQPR RCSPFCRARL SLGALAAFVL ALLLGAEPES WAAGAAWLRT LLSVCSHSLS
   121  PLFSIACAFF FLTCFLTRTK RGPGPGRSCG SWWLLALPAC CYLGDFLVWQ WWSWPWGDGD
   181  AGSAAPHTPP EAAAGRLLLV LSCVGLLLTL AHPLRLRHCV LVLLLASFVW WVSFTSLGSL
   241  PSALRPLLSG LVGGAGCLLA LGLDHFFQIR EAPLHPRLSS AAEEKVPVIR PRRRSSCVSL
   301  GETAASYYGS CKIFRRPSLP CISREQMILW DWDLKQWYKP HYQNSGGGNG VDLSVLNEAR
   361  NMVSDLLTDP SLPPQVISSL RSISSLMGAF SGSCRPKINP LTPFPGFYPC SEIEDPAEKG
   421  DRKLNKGLNR NSLPTPQLRR SSGTSGLLPV EQSSRWDRNN GKRPHQEFGI SSQGCYLNGP
   481  FNSNLLTIPK QRSSSVSLTH HVGLRRAGVL SSLSPVNSSN HGPVSTGSLT NRSPIEFPDT
   541  ADFLNKPSVI LQRSLGNAPN TPDFYQQLRN SDSNLCNSCG HQMLKYVSTS ESDGTDCCSG
   601  KSGEEENIFS KESFKLMETQ QEEETEKKDS RKLFQEGDKW LTEEAQSEQQ TNIEQEVSLD
   661  LILVEEYDSL IEKMSNWNFP IFELVEKMGE KSGRILSQVM YTLFQDTGLL EIFKIPTQQF
   721  MNYFRALENG YRDIPYHNRI HATDVLHAVW YLTTRPVPGL QQIHNGCGTG NETDSDGRIN
   781  HGRIAYISSK SCSNPDESYG CLSSNIPALE LMALYVAAAM HDYDHPGRTN AFLVATNAPQ
   841  AVLYNDRSVL ENHHAASAWN LYLSRPEYNF LLHLDHVEFK RFRFLVIEAI LATDLKKHFD
   901  FLAEFNAKAN DVNSNGIEWS NENDRLLVCQ VCIKLADING PAKVRDLHLK WTEGIVNEFY
   961  EQGDEEANLG LPISPFMDRS SPQLAKLQES FITHIVGPLC NSYDAAGLLP GQWLEAEEDN
  1021  DTESGDDEDG EELDTEDEEM ENNLNPKPPR RKSRRRIFCQ LMHHLTENHK IWKEIVEEEE
  1081  KCKADGNKLQ VENSSLPQAD EIQVIEEADE EE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDE3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 61 nTPM
  • liver: 24 nTPM
  • colon: 24 nTPM
  • lymph node: 14 nTPM
  • salivary gland: 13 nTPM
  • breast: 12 nTPM

Single-cell type

  • adipocytes: 2,847 nCPM
  • neutrophils: 1,417 nCPM
  • t-cells: 827 nCPM
  • thyrotrophs: 539 nCPM
  • salivary acinar cells: 515 nCPM
  • microglia: 490 nCPM

Immune cell

  • naive CD4 T-cell: 6.3 nTPM
  • naive CD8 T-cell: 5.7 nTPM
  • neutrophil: 3.9 nTPM
  • T-reg: 3.5 nTPM
  • memory CD4 T-cell: 3.1 nTPM
  • eosinophil: 2.5 nTPM

Brain region

  • cerebellum: 32 nTPM
  • medulla oblongata: 9.7 nTPM
  • white matter: 9.5 nTPM
  • hypothalamus: 9.3 nTPM
  • cerebral cortex: 9.1 nTPM
  • spinal cord: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0
gnomAD missense Z
0.05
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDE3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDE3B as an antibody target. Whether an autoantibody or antibody against PDE3B could matter depends on whether native PDE3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDE3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDE3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDE3B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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